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首页> 外文期刊>Future medicinal chemistry >Combating chronic bacterial infections by manipulating cyclic nucleotide-regulated biofilm formation
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Combating chronic bacterial infections by manipulating cyclic nucleotide-regulated biofilm formation

机译：通过控制环核苷酸调控的生物膜形成来对抗慢性细菌感染

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摘要

Many pathogenic bacteria can form biofilms in clinical settings with major consequences for the progression of infections. Bacterial biofilm communities are typically much more resistant to both antibiotic treatment and clearance by the immune system in comparison to free-living cells. Therefore, drugs that specifically target the formation or maintenance of biofilms would be very valuable additions to current clinical options. Cyclic nucleotide second messengers, in particular cyclic-diguanosine-GMP (c-di-GMP), are now known to play a major role in biofilm formation, and maintenance, in many bacterial species. In this special report, we will review recent progress toward the development of drugs that interfere with c-diguanosine-GMP signaling as a route to control biofilm infections. We will focus on the chronic infections associated with the notorious opportunistic pathogen Pseudomonas aeruginosa, although the principles outlined here are also relevant to most bacterial pathogens.
机译：在临床环境中，许多致病细菌会形成生物膜，对感染的进展产生重大影响。与自由活动细胞相比，细菌生物膜群落通常对抗生素治疗和免疫系统清除具有更大的抵抗力。因此，专门针对生物膜形成或维持的药物将是当前临床选择中非常有价值的补充。现在已知环状核苷酸第二信使，特别是环状双鸟苷-GMP（c-di-GMP）在许多细菌物种的生物膜形成和维持中起主要作用。在本特别报告中，我们将回顾开发干扰c-双鸟苷-GMP信号作为控制生物膜感染途径的药物的最新进展。尽管此处概述的原理也与大多数细菌性病原体有关，但我们将重点关注与臭名昭著的机会性病原体铜绿假单胞菌相关的慢性感染。

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