Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for RGD-Modification and Hydrogel Formation

Yi Su; Ji?í Pale?ek; Andreas Kirschning; Gerald Dr?ger

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Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for RGD-Modification and Hydrogel Formation

机译：用于RGD修饰和水凝胶形成的多唾液酸的铜介导和无铜“点击”修饰

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This paper describes and compares the copper-catalyzed and copperfree “click” reaction of N-azido, N-alkynoyl and N-oxanorbornadienyl polysialic acid for the formation of hydrogels and cyclic RGD conjugates. To proof the molecular mechanism of the crosslinking reaction, the crosslinking and conjugation reactions were studied in detail on a molecular level by 1H-NMR spectroscopy and mass spectrometry as well as MS/MS experiments identifying the non-hydrolyzable crosslinks.

机译：本文描述并比较了N-叠氮基，N-炔基和N-氧杂降冰片二烯基聚唾液酸的铜催化和无铜“点击”反应，以形成水凝胶和环状RGD共轭物。为了证明交联反应的分子机理，通过1 H-NMR光谱和质谱以及鉴定非水解性交联的MS / MS实验，在分子水平上详细研究了交联和共轭反应。

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来源
《Macromolecular symposia》 |2013年第1期|共10页
作者
Yi Su; Ji?í Pale?ek; Andreas Kirschning; Gerald Dr?ger;
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正文语种 eng
中图分类高分子化学（高聚物）;
关键词
click chemistry; hydrogel; polysialic acid; RGD-peptide;

机译：点击化学;水凝胶;聚唾液酸;RGD-肽;

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1. Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for RGD-Modification and Hydrogel Formation [J] . Yi Su, Ji?í Pale?ek, Andreas Kirschning, Macromolecular symposia . 2013,第1期

机译：用于RGD修饰和水凝胶形成的多唾液酸的铜介导和无铜“点击”修饰
2. Biodegradable DNA-enabled poly(ethylene glycol) hydrogels prepared by copper-free click chemistry [J] . Barker Karolyn, Rastogi Shiva K., Dominguez Jose, Journal of biomaterials science . 2016,第1a3期

机译：通过无铜点击化学法制备的可生物降解的DNA活化聚（乙二醇）水凝胶
3. In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide-alkyne click reaction for tissue engineering [J] . Vinh X. Truong, Matthew P. Ablett, Hamish T. J. Gilbert, Biomaterials Science . 2014,第2期

机译：无铜叠氮化物-炔炔点击反应制备的原位形成的壳聚糖-聚乙二醇水凝胶，用于组织工程
4. Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for RGD-Modification and Hydrogel Formation [C] . Yi Su, Jiri Palecek, Andreas Kirschning Advanced Functional Polymers for Medicine . 2013

机译：铜介导和铜无“点击”核苷酸的装饰，用于RGD改性和水凝胶形成
5. Copper(II) oxide mediated formation and stabilization of combustion generated persistent free radicals. [D] . Truong, Hieu. 2007

机译：氧化铜（II）介导的燃烧形成和稳定产生了持久性自由基。
6. Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Crosslinked by Copper-free Strain-promoted Click Chemistry [O] . Jianwen Xu, Tera M. Filion, Fioleda Prifti, -1

机译：细胞偶联聚（乙二醇）-Co-聚碳酸酯水凝胶通过无铜应变促进的点击化学
7. In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide-alkyne click reaction for tissue engineering [O] . Truong, Vinh X., Ablett, Matthew P., Gilbert, Hamish T J, 2014

机译：由无铜叠氮化物 - 炔烃点击反应制备的原位形成稳健的壳聚糖 - 聚（乙二醇）水凝胶用于组织工程
8. The Interaction of Hydrazine with Copper(II) Chloride in Acidic Solutions. The Formation, Spectral and Magnetic Properties, and Structures of Copper(II), Copper(I), and Mixed Valence Species. [R] . Brown, D. B., Donner, J. A., Hall, J. W., 1979

机译：肼与氯化铜（II）在酸性溶液中的相互作用。铜（II），铜（I）和混合价物种的形成，光谱和磁性以及结构。

Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for RGD-Modification and Hydrogel Formation

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