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首页> 外文期刊>Macromolecular symposia >Loading of bacterial cellulose aerogels with bioactive compounds by antisolvent precipitation with supercritical carbon dioxide
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Loading of bacterial cellulose aerogels with bioactive compounds by antisolvent precipitation with supercritical carbon dioxide

机译：通过超临界二氧化碳的反溶剂沉淀将生物活性化合物负载在细菌纤维素气凝胶中

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摘要

Bacterial cellulose aerogels overcome the drawback of shrinking during preparation by drying with supercritical CO_2. Thus, the pore network of these gels is fully accessible. These materials can be fully rewetted to 100% of its initial water content, without collapsing of the structure due to surface tension of the rewetting solvent. This rehydration property and the high pore volume of these material rendered bacterial cellulose aerogels very interesting as controlled release matrices. Supercritical CO_2 drying, the method of choice for aerogel preparation, can simultaneously be used to precipitate solutes within the cellulose matrix and thus to load bacterial cellulose aerogels with active substances. This process, frequently termed supercritical antisolvent precipitation, is able to perform production of the actual aerogel and its loading in one single preparation step. In this work, the loading of a bacterial cellulose aerogel matrix with two model substances, namely dexpanthenol and L-ascorbic acid, and the release behavior from the matrix were studied. A mathematical release model was applied to model the interactions between the solutes and the cellulose matrix. The bacterial cellulose aerogels were easily equipped with the reagents by supercritical antisolvent precipitation. Loading isotherms as well as release kinetics indicated no specific interaction between matrix and loaded substances. Hence, loading and release can be controlled and predicted just by varying the thickness of the gel and the solute concentration in the loading bath.
机译：细菌纤维素气凝胶克服了制备过程中通过用超临界CO_2干燥而收缩的缺点。因此，这些凝胶的孔网络是完全可及的。可以将这些材料重新润湿至其初始含水量的100％，而不会因再润湿溶剂的表面张力而使结构塌陷。这些材料的这种再水化性质和高孔体积使得细菌纤维素气凝胶作为控释基质非常有趣。超临界CO_2干燥是气凝胶制备的一种选择方法，可同时用于在纤维素基质中沉淀溶质，从而使细菌纤维素气凝胶中充满活性物质。这一过程（通常称为超临界抗溶剂沉淀）能够在一个单独的制备步骤中完成实际气凝胶的生产及其负载。在这项工作中，研究了一种细菌模型气凝胶基质中载有两种模型物质，即右泛醇和L-抗坏血酸，以及从基质中的释放行为。应用数学释放模型来模拟溶质和纤维素基质之间的相互作用。通过超临界抗溶剂沉淀，细菌纤维素气凝胶很容易配备试剂。负载等温线以及释放动力学表明基质与负载物质之间没有特定的相互作用。因此，仅通过改变凝胶的厚度和加载浴中的溶质浓度就可以控制和预测加载和释放。

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