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首页> 外文期刊>Macromolecular theory and simulations >Mathematical model for surface-initiated photopolymerization of poly(ethylene glycol) diacrylate
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Mathematical model for surface-initiated photopolymerization of poly(ethylene glycol) diacrylate

机译：聚乙二醇二丙烯酸酯表面引发光聚合的数学模型

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A general mathematical model has been developed to describe the surface initiated photopolymerization of PEG-DA forming crosslinked hydrogel membranes upon the surface of a substrate. Such membranes are formed by photopolymerizing a PEG-DA prepolymer solution by initiation with eosin-Y-functionalized surfaces and TEA using VP as accelerator. Experimental measurements of the thickness of hydrogel membranes compare well with the model. The model is developed by using the pseudo-kinetic approach and the method of moments, and is capable of predicting the crosslink density and thickness of the hydrogel membrane. Parametric sensitivity of the effects of PEG-DA, VP and coinitiator TEA concentration towards the crosslink density and the thickness of the hydrogel is also investigated. The results obtained for different PEG-DA and VP concentrations suggest that the concentration ratio of these two monomers is a key parameter in controlling the gel thickness and permeability. This model can also be applied to systems where drugs, proteins or cells are encapsulated through surface initiated photopolymerization to predict the growth and crosslink density profiles of the encapsulating membrane. In a previous study we have experimentally demonstrated that these membranes could be made to attack covalently to the surface of the underlying substrate.
机译：已经开发出通用数学模型来描述在基材表面上形成交联的水凝胶膜的PEG-DA的表面引发的光聚合。通过用曙红-Y-官能化表面和使用VP作为促进剂的TEA引发光聚合PEG-DA预聚物溶液来形成这种膜。水凝胶膜厚度的实验测量结果与该模型进行了比较。该模型是使用拟动力学方法和矩量法开发的，能够预测水凝胶膜的交联密度和厚度。还研究了PEG-DA，VP和共引发剂TEA浓度对交联密度和水凝胶厚度的影响的参数敏感性。对于不同的PEG-DA和VP浓度获得的结果表明，这两种单体的浓度比是控制凝胶厚度和渗透性的关键参数。该模型还可以应用于通过表面引发的光聚合作用来封装药物，蛋白质或细胞以预测封装膜的生长和交联密度分布的系统。在先前的研究中，我们已通过实验证明，这些膜可被制成共价作用于下面的底物表面。

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