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首页> 外文期刊>Canadian journal of anesthesia: Journal canadien d'anesthesie >Neuromuscular effects of rapacuronium in pediatric patients during nitrous oxide-halothane anesthesia: comparison with mivacurium.
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Neuromuscular effects of rapacuronium in pediatric patients during nitrous oxide-halothane anesthesia: comparison with mivacurium.

机译：一氧化二氮-氟烷麻醉期间小儿ra虫uro的神经肌肉作用：与米伐库溴铵比较。

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PURPOSE: To describe neuromuscular effects of rapacuronium in pediatric patients during N2O-halothane anesthesia and compare them with mivacurium in children. METHODS: 103 pediatric patients, seven days -12 yr, received rapacuronium or mivacurium during N2O-halothane anesthesia. Onset and recovery of block were measured using EMG (Datex). Block was compared between groups based on drug treatment and age. Children < two years received 1 or 2 mg x kg(-1) rapacuronium: 2-12 yr received either 2 mg x kg(-1) or 3 mg x kg(-1) rapacuronium, or 0.2 mg x kg(-1) mivacurium. RESULTS: There were no differences in onset (1.7+/-1.8 min) or maximum block (T1 2.4+/-8%) among neonates, infants, and toddlers after either dose of rapacuronium. There was no difference between 1 and 2 mg x kg(-1) of rapacuronium block at 60 sec. Train-of-four ratio (T4/T1) >0.7 occurred later after 2 mg x kg(-1) than 1 mg x kg(-1) in these patients (P<0.05). There was no difference in T25 among neonates, infants and toddlers for 1 mg x kg(-1) or 2 mg x kg(-1) doses. Rapacuronium, 3 mg x kg(-1), produced maximum block 1.5 min earlier than did mivacurium, 0.2 mg x kg(-1) (P<0.001). There was no difference in block at 60 sec, maximum block or time to maximum block between 2 and 3 mg x kg(-1) rapacuronium for children > two years of age. Maximum block occurred 1.0+/-0.5 min after 2 or 3 mg x kg(-1) when T1 was 0.2+/-1.1% of baseline. T25 and T4/T1 >0.7 occurred 10 to 11 min later after this dose of rapacuronium than after mivacurium. CONCLUSION: Rapacuronium produces block earlier than mivacurium. Recovery from rapacuronium block is dose related and slower than that following mivacurium during halothane anesthesia.
机译：目的：描述ra草铵在小儿N2O-氟烷麻醉中对小儿患者的神经肌肉作用，并将其与儿童米维库仑进行比较。方法：103名小儿患者，在7天-12年内，在N2O-氟烷麻醉期间接受了雷古溴铵或米库溴铵的治疗。使用EMG（Datex）测量阻滞的发作和恢复。根据药物治疗和年龄在各组之间比较Block。小于2岁的儿童接受1或2 mg x kg（-1）的雷古uro草：2-12岁接受2 mg x kg（-1）或3 mg x kg（-1）的雷古pac草或0.2 mg x kg（-1） ）mivacurium。结果：两种剂量的雷帕pac溴铵治疗后，新生儿，婴儿和学步儿童的发作（1.7 +/- 1.8分钟）或最大阻滞（T1 2.4 +/- 8％）均无差异。在60秒时1和2 mg x kg（-1）的pac草素阻滞之间没有差异。在这些患者中，2 mg x kg（-1）比四毫克比率（T4 / T1）> 1 mg x kg（-1）出现晚（P <0.05）。 1 mg x kg（-1）或2 mg x kg（-1）剂量的新生儿，婴幼儿中的T25没有差异。 3 mg x kg（-1）的雷古uro碱比mivacurium 0.2 mg x kg（-1）产生的最大阻滞提前1.5分钟（P <0.001）。对于年龄大于2岁的儿童，在60秒，最大阻滞或最大阻滞时间在2到3 mg x kg（-1）pac螺uro之间没有差异。当T1为基线的0.2 +/- 1.1％时，最大阻塞发生在2或3 mg x kg（-1）后1.0 +/- 0.5分钟。服用雷帕溴铵比使用米伐库仑晚10至11分钟，T25和T4 / T1> 0.7发生。结论：雷古uro碱比维库溴铵更早产生嵌段。在氟烷麻醉期间，从ra草嘧啶阻滞剂中恢复的剂量与剂量相关，并且比米维库溴铵缓慢。

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