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首页> 外文期刊>Canadian journal of anesthesia: Journal canadien d'anesthesie >Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats: (La cardioprotection contre les lesions de reperfusion est maximale apres deux minutes seulement d'administration de sevoflurane chez
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Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats: (La cardioprotection contre les lesions de reperfusion est maximale apres deux minutes seulement d'administration de sevoflurane chez

机译：在大鼠中仅用两分钟的七氟醚，对再灌注损伤的心脏保护最大：在大鼠中仅用两分钟的七氟醚，对心脏的再灌注损伤是最大的。

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PURPOSE: Volatile anesthetics can protect the heart against reperfusion injury. When sevoflurane is given for the first 15 min of reperfusion, a concentration corresponding to one minimum alveolar concentration (MAC) provides a maximum protective effect. The present study addresses the question of how long sevoflurane has to be administered to achieve the best cardioprotection. METHODS: Chloralose anesthetized rats were subjected to a 25-min occlusion of a major coronary artery, followed by 90 min of reperfusion. During the initial phase of reperfusion, an end-tidal concentration of 2.4 vol.% of sevoflurane (1 MAC) was given for two (n = 8), five (n = 8) or ten minutes (n = 7). Seven rats served as untreated controls. We measured left ventricular (LV) pressure, mean aortic pressure and infarct size (triphenyltetrazolium staining). RESULTS: Administration of sevoflurane for two minutes resulted in the greatest reduction of infarct size to 15% (8-22 [mean (95% confidence interval)] of the area at risk compared with controls [51 (47-55) %, P < 0.001]. Five or ten minutes of sevoflurane administration reduced infarct size to 26 (18-34) and 26 (18-35) % [P < 0.05], respectively. The cardiodepressant effect of sevoflurane varied with the duration of its administration: LV dP/dt was reduced from 6332 mmHg*sec(-1) (5771-6894) during baseline to 4211 mmHg*sec(-1) (3031-5391), 3811 mmHg*sec(-1) (2081-5540) and 3612 mmHg*sec(-1) (2864-4359) after two, five and ten minutes of reperfusion, respectively. CONCLUSION: Administration of 1 MAC sevoflurane for the first two minutes of reperfusion effectively protects the heart against reperfusion injury in rats in vivo. A longer administration time had lesser cardioprotective effects in this experimental model.
机译：目的：挥发性麻醉药可以保护心脏免受再灌注损伤。在再灌注的前15分钟内给予七氟醚时，相当于一个最小肺泡浓度（MAC）的浓度可提供最大的保护作用。本研究解决了七氟醚必须服用多长时间才能达到最佳心脏保护的问题。方法：将经氯醛糖麻醉的大鼠的主要冠状动脉闭塞25分钟，然后再灌注90分钟。在再灌注的初始阶段，在两（n = 8），五（n = 8）或十分钟（n = 7）的潮气末浓度为2.4 vol。％的七氟醚（1 MAC）。七只大鼠作为未治疗的对照。我们测量了左心室（LV）压力，主动脉平均压力和梗死面积（三苯四唑染色）。结果：与对照组相比，七氟醚给药2分钟可使梗塞面积最大减少至危险区域的15％（平均风险范围为8-22 [平均（95％置信区间）] [51（47-55）％，P <0.001]。七氟醚给药5分钟或10分钟可使梗塞面积分别减少至26（18-34）和26（18-35）％[P <0.05]。七氟醚的抗抑郁作用随给药时间的延长而变化： LV dP / dt从基线期间的6332 mmHg * sec（-1）（3031-6391）降低到基线期间的4211 mmHg * sec（-1）（3031-5391），3811 mmHg * sec（-1）（2081-5540）结论：在再灌注的前两分钟内分别注射1个MAC七氟醚可有效保护心脏免受再灌注损伤，并且分别在再灌注两分钟，五分钟和十分钟后达到3612 mmHg * sec（-1）（2864-4359）。在此实验模型中，较长的给药时间对心脏的保护作用较小。

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