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首页> 外文期刊>Macromolecular chemistry and physics >Synthesis of Monodisperse Sequence-Defined Polymers Using Protecting-Group-Free Iterative Strategies
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Synthesis of Monodisperse Sequence-Defined Polymers Using Protecting-Group-Free Iterative Strategies

机译：使用无保护基团的迭代策略合成单分散序列定义的聚合物

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摘要

The synthesis of "precision" polymers with finely controlled molecular structures is an important new development in synthetic polymer chemistry. This trend is the logical outcome of the continuing evolution of the field of polymer synthesis. Indeed, during the last few decades, synthetic tools, such as living ionic polymerizations, controlled radical polymerizations, and click chemistry, have revolutionized the synthesis of polymers with controlled architectures such as block, graft, star, brush, hyperbranched or cyclic polymers. These aspects being solved, it is now time for polymer chemists to address more challenging questions such as the design of monodisperse polymers and the control of primary (i.e., comonomer sequences), secondary (i.e., single-chain folding), and tertiary (i.e., single-chain compartmentalization) structures. Here, new synthetic tools have to be developed or imported from other disciplines such as organic chemistry and biochemistry. For instance, solid-phase iterative chemistry, which was initially introduced for the synthesis of oligopeptides and oligonucleotides, is an interesting methodology for preparing monodisperse sequence-defined polymers. However, such approaches are usually time-consuming and request demanding coupling/capping/deprotection steps. Yet, interesting protecting-group-free methodologies have been described in recent years for simplifying and accelerating these processes. These promising new approaches are briefly listed and explained in this article.
机译：具有精确控制的分子结构的“精密”聚合物的合成是合成聚合物化学中的重要新进展。这种趋势是聚合物合成领域不断发展的逻辑结果。实际上，在过去的几十年中，诸如活性离子聚合，受控的自由基聚合和点击化学之类的合成工具已经彻底改变了具有受控结构的聚合物的合成，例如嵌段，接枝，星形，刷子，超支化或环状聚合物。这些方面已得到解决，现在是聚合物化学家解决更具挑战性的问题的时候了，例如单分散聚合物的设计以及一级（即共聚单体序列），二级（即单链折叠）和三级（即三级）的控制，单链划分）结构。在这里，必须从有机化学和生物化学等其他学科开发或导入新的合成工具。例如，固相迭代化学是最初用于合成寡肽和寡核苷酸的方法，是制备单分散序列定义的聚合物的有趣方法。然而，这样的方法通常是费时的并且要求苛刻的耦合/封盖/去保护步骤。然而，近年来已经描述了用于简化和加速这些过程的有趣的无保护基团的方法。本文简要列出并解释了这些有希望的新方法。

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