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首页> 外文期刊>Macromolecular theory and simulations >Modeling of free-radical crosslinking copolymerization of acrylamide and N,N '-methylenebis(acrylamide) for radiation dosimetry
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Modeling of free-radical crosslinking copolymerization of acrylamide and N,N '-methylenebis(acrylamide) for radiation dosimetry

机译：辐射剂量法对丙烯酰胺与N，N'-亚甲基双（丙烯酰胺）的自由基交联共聚进行建模

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摘要

Over the past decade there has been much interest in the development of three-dimensional gel dosimeters to aid in the determination of the distribution and magnitude of absorbed dose in clinical radiation therapy. A widely used dosimeter for verification of spatial dose distribution is the polyacrylamide system, sometimes termed polyacrylamide gel (PAG). In this paper, we develop a model to describe the kinetic mechanisms in this gel dosimeter, based on the radiation-induced copolymerization of acrylamide and bisacrylamide monomers in water and gelatin. Using the proposed model, the conversion of both monomers and total vinyl groups, the concentrations of pendant double bonds (PDB), cyclized groups and crosslinks along the polymer chains as well as temperature changes were simulated. The model predictions and experimental findings in PAG dosimeters agree for a variety of recipes and spatially uniform radiation conditions. Further experiments are required to obtain accurate kinetic parameter estimates and to verify model predictions. [References: 43]
机译：在过去的十年中，人们对三维凝胶剂量计的发展非常感兴趣，以帮助确定临床放射治疗中吸收剂量的分布和大小。用于验证空间剂量分布的广泛使用的剂量计是聚丙烯酰胺系统，有时也称为聚丙烯酰胺凝胶（PAG）。在本文中，我们基于辐射诱导的丙烯酰胺和双丙烯酰胺单体在水和明胶中的共聚反应，开发了一个模型来描述该凝胶剂量计的动力学机理。使用所提出的模型，模拟了单体和总乙烯基的转化，侧链双键（PDB）的浓度，沿聚合物链的环化基团和交联以及温度变化。 PAG剂量计中的模型预测结果和实验结果符合各种配方和空间均匀辐射条件。需要进一步的实验以获得准确的动力学参数估计并验证模型预测。 [参考：43]

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