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首页> 外文期刊>Macromolecular chemistry and physics >Dual UV- and pH-Responsive Supramolecular Vesicles Mediated by Host-Guest Interactions for Drug Controlled Release
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Dual UV- and pH-Responsive Supramolecular Vesicles Mediated by Host-Guest Interactions for Drug Controlled Release

机译：宿主与客体相互作用介导的对UV和pH敏感的双重超分子囊泡，用于药物控释

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摘要

To control the release of the drugs at specific time and location, dual UV- and pH-responsive supramolecular vesicles are described mediated by host-guest interactions. The hydrophobic segment beta-CD-Azo-Ace (where beta-CD, Azo, and Ace refer to beta-cyclodextrin, azobenzene, and acetal, respectively) forms the inclusion with alpha-CD and the inclusion further self-assembles to form supramolecular vesicles in aqueous medium. The nanospherical supramolecular vesicles are approximate to 50 nm and high-efficiently load the drugs. Furthermore, supramolecular vesicles are dual UV- and pH-responsive, thus release the drugs at specific time (stimulated by UV) and location (stimulated by pH), which will have significant advantages for cancer treatment.
机译：为了控制药物在特定时间和位置的释放，描述了由宿主-客体相互作用介导的对UV和pH有响应的超分子双泡。疏水链段β-CD-偶氮-Ace（其中β-CD，Azo和Ace分别指β-环糊精，偶氮苯和乙缩醛）与α-CD形成内含物，并且该内含物进一步自组装形成超分子水性介质中的囊泡。纳米球形超分子囊泡约为50 nm，可高效负载药物。此外，超分子囊泡对紫外线和pH都有双重反应，因此会在特定时间（受紫外线刺激）和部位（受pH刺激）释放药物，这对于癌症治疗将具有显着优势。

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