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首页> 外文期刊>Magnetic resonance in medicine: official journal of the Society of Magnetic Resonance in Medicine >Quantification of bolus-tracking MRI: Improved characterization of the tissue residue function using Tikhonov regularization.
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Quantification of bolus-tracking MRI: Improved characterization of the tissue residue function using Tikhonov regularization.

机译：大剂量追踪MRI的定量：使用Tikhonov正则化改进了组织残留功能的表征。

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摘要

Quantification of cerebral blood flow (CBF) and the tissue residue function (R) using bolus-tracking MRI requires deconvolution of the arterial input function (AIF). Currently, the most commonly used deconvolution method is singular value decomposition (SVD), which has been shown to produce accurate estimations of CBF. However, this method introduces unwanted oscillations in the time course of R, and there are situations in which the actual shape is of interest (e.g., in calculating flow heterogeneity and assessing bolus dispersion). In such cases, the conventional SVD method may no longer be suitable, and an alternative approach may be required. This work describes the implementation of Tikhonov regularization with the L-curve criterion to quantify CBF and obtain a better characterization of R. The methodology is tested on simulated and patient data, and the results are compared to those found using the conventional SVD approach. Although both methods produce similar CBF values, the deconvolved R shape obtained using SVD is dominated by oscillations and fails to characterize the shape in the presence of dispersion. On the other hand, the use of the proposed regularization method improves the characterization of the tissue residue function. Magn Reson Med 50:1237-1247, 2003. Copyright 2003 Wiley-Liss, Inc.
机译：使用大剂量追踪MRI对脑血流量（CBF）和组织残留功能（R）进行量化需要对动脉输入功能（AIF）进行反卷积。当前，最常用的反卷积方法是奇异值分解（SVD），已证明该方法可以生成CBF的准确估计值。然而，该方法在R的时间过程中引入了不希望的振荡，并且在某些情况下，实际形状是令人关注的（例如，在计算流动非均质性和评估弹丸扩散时）。在这种情况下，常规的SVD方法可能不再适用，并且可能需要替代方法。这项工作描述了使用L曲线标准进行Tikhonov正则化以量化CBF并获得更好的R表征的方法。该方法在模拟和患者数据上进行了测试，并将结果与​​使用常规SVD方法得到的结果进行了比较。尽管两种方法都产生相似的CBF值，但使用SVD获得的反卷积R形状受振荡支配，并且在存在色散时无法表征该形状。另一方面，所提出的正则化方法的使用改善了组织残余功能的表征。 Magn Reson Med 50：1237-1247，2003。版权所有2003 Wiley-Liss，Inc.。

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