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首页> 外文期刊>Mammalian genome: official journal of the International Mammalian Genome Society >Investigation of TXNIP (thioredoxin-interacting protein) and TRX (thioredoxin) genes for growth-related traits in pigs.
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Investigation of TXNIP (thioredoxin-interacting protein) and TRX (thioredoxin) genes for growth-related traits in pigs.

机译：猪生长相关性状的TXNIP（硫氧还蛋白相互作用蛋白）和TRX（硫氧还蛋白）基因的研究。

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摘要

It is well known that TRX and its endogenous inhibitor TXNIP help sustain the cellular reduction/oxidation balance in response to various stresses and both play a crucial role in cell proliferation and growth. Five SNPs were found in TXNIP and these allowed us to map it by linkage to SSC4. Three of the SNPs were used for association analyses in three commercial pig populations (Duroc, Hampshire, and synthetic line) with more than 1200 animals. Both the single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain. TRX was mapped on SSC1 but no significant associations with growth-related traits were found in the synthetic pig line in which the SNP was informative. The expression levels of TXNIP and TRX were then detected in two groups (fast growth and slow growth, respectively) with different genetic backgrounds for growth. Compared with the slow-growth group, TXNIP expression was significantly lower in the fast-growth group, whereas a marked increase in TRX expression was observed in fast-growth group. Our findings suggest that TXNIP has effects on growth-related traits in pigs and further investigations will be necessary to elucidate the underlying mechanisms involved.
机译：众所周知，TRX及其内源性抑制剂TXNIP有助于维持细胞在各种压力下的还原/氧化平衡，并且两者在细胞增殖和生长中都起着至关重要的作用。在TXNIP中发现了五个SNP，这些SNP使我们可以通过链接到SSC4对其进行映射。其中三个SNP用于与超过1200只动物的三个商业猪种群（Duroc，Hampshire和合成系）的关联分析。单标记和单倍型分析均显示TXNIP对hot体重量，测试日增重和终生日增重有显着影响。 TRX被定位在SSC1上，但是在SNP可以提供信息的合成猪系中，没有发现与生长相关性状的显着关联。然后在具有不同生长遗传背景的两组（分别为快速生长和缓慢生长）中检测TXNIP和TRX的表达水平。与慢增长组相比，快增长组的TXNIP表达明显降低，而快增长组的TRX表达显着增加。我们的发现表明TXNIP对猪的生长相关性状有影响，因此有必要进行进一步的研究以阐明其潜在的机制。

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