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首页> 外文期刊>Frontiers in bioscience: a journal and virtual library >Induction of allograft tolerance in nonhuman primates and humans.
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Induction of allograft tolerance in nonhuman primates and humans.

机译：在非人类灵长类动物和人类中诱导同种异体移植耐受性。

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Despite remarkable improvement in short-term survival following organ transplantation, long-term results have been less satisfactory, mainly due to chronic rejection or toxicities induced by immunosuppressive drugs. Therefore, induction of specific immunologic tolerance remains an important goal in organ transplantation. Although numerous regimens for the induction of allograft tolerance have been developed in rodents, their application to large animal models has been limited. The mechanisms of action of the approaches that have been successfully applied in monkey models can be divided into three major categories: 1) deletion, 2) co-stimulatory blockade and 3) regulation. Long-term allograft survival has now been achieved in several nonhuman primate models; however, late-onset chronic rejection as well as the toxicity of some of these regimens remain as significant limitations that hamper clinical application.
机译：尽管器官移植后的短期存活率有了显着改善，但长期结果仍较不令人满意，这主要是由于慢性排斥反应或免疫抑制药物引起的毒性所致。因此，诱导特异性免疫耐受仍然是器官移植的重要目标。尽管已经在啮齿动物中开发了许多诱导同种异体移植耐受性的方案，但是它们在大型动物模型中的应用受到限制。已成功应用于猴子模型的方法的作用机制可分为三大类：1）删除，2）共刺激性阻断和3）调节。现在已经在几种非人类灵长类动物模型中实现了长期同种异体移植的存活。然而，迟发性慢性排斥反应以及其中某些方案的毒性仍然是阻碍临床应用的重大局限性。

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