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首页> 外文期刊>Frontiers in bioscience: a journal and virtual library >Beta-amyloid peptide--nicotinic acetylcholine receptor interaction: the two faces of health and disease.
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Beta-amyloid peptide--nicotinic acetylcholine receptor interaction: the two faces of health and disease.

机译：β-淀粉样肽-烟碱乙酰胆碱受体相互作用：健康和疾病的两个方面。

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摘要

Elevated amyloid-beta peptide (Abeta) and loss of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery of an Abeta-nAChR interaction, much effort has been expended to understand how this interaction may contribute to normal physiological processes as well as AD. Several researchers have expanded on the initial observation of an Abeta-nAChR interaction to characterize the pertinent factors that confer Abeta sensitivity to nAChRs. Some of which include the following: 1. receptor subunit composition; 2. receptor subunit stoichiometry; 3. regional distribution; 4. presynaptic versus somatic distribution; 5. neuron versus glia expression; 6. in vitro expression system. These aspects of nAChR composition and expression appear to confer the specific functional consequences of Abeta interaction which range from blockade of receptor activation to stimulation of second messenger cascades that provide neuroprotection from Abeta toxicity. This review will discuss the extant literature on the subject in terms of clarifying this apparent dichotomy regarding the consequences of Abeta-nAChR interaction during health and disease.
机译：在阿尔茨海默氏病（AD）的病因学中，淀粉样β肽（Abeta）升高和烟碱型乙酰胆碱受体（nAChRs）丢失尤为突出。自发现Abeta-nAChR相互作用以来，已花费大量精力来理解这种相互作用如何对正常的生理过程以及AD起作用。一些研究人员已经扩大了对Abeta-nAChR相互作用的初步观察，以表征赋予Abeta对nAChRs敏感性的相关因素。其中一些包括：1.受体亚基组成; 2.受体亚单位化学计量; 3.区域分布; 4.突触前与躯体分布; 5.神经元与胶质细胞表达; 6.体外表达系统。 nAChR组成和表达的这些方面似乎赋予了Abeta相互作用特定的功能性后果，范围从受体激活的阻断到刺激提供神经保护免受Abeta毒性的第二信使级联。这篇综述将讨论有关该主题的现有文献，以阐明这种有关健康和疾病期间Abeta-nAChR相互作用后果的明显二分法。

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