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首页> 外文期刊>Frontiers in bioscience: a journal and virtual library >Class IIA HDACs in the regulation of neurodegeneration.
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Class IIA HDACs in the regulation of neurodegeneration.

机译：IIA类HDAC在神经变性的调节中。

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Neurodegenerative diseases affect millions of patients annually and are a significant burden on the health care systems around the world. While there are symptomatic remedies for patients suffering from various neurodegenerative diseases, there are no cures as of today. Cell death by apoptosis is a common hallmark of neurodegeneration. Therefore, deciphering the molecular pathways regulating this process is of significant value to scientists' endeavor to understand neurodegenerative disorders. Efforts along these lines have uncovered a number of molecular pathways that regulate neuronal apoptosis. Recently, a family of proteins known as histone deacetylases (HDACs) has been linked to regulation of cell survival as well as death. The focus of this review is to summarize our current understanding of the role of HDACs and in particular a subgroup of proteins in this family classified as class IIa HDACs in the regulation of neuronal cell death. It is apparent based on the information presented in this review that although very similar in their primary sequence, members of this family of proteins often have distinct roles in orchestrating apoptotic cell death in the brain.
机译：神经退行性疾病每年影响数百万患者，并且是全世界医疗保健系统的重大负担。尽管有针对各种神经退行性疾病的患者的对症疗法，但迄今为止尚无治愈方法。凋亡引起的细胞死亡是神经变性的常见标志。因此，破译调控这一过程的分子途径对科学家了解神经退行性疾病的努力具有重要价值。沿着这些方向的努力已经发现了许多调节神经元凋亡的分子途径。最近，一种称为组蛋白脱乙酰基酶（HDACs）的蛋白质家族已与细胞存活以及死亡的调控联系在一起。这篇综述的重点是总结我们目前对HDAC的作用的理解，尤其是该家族中被分类为IIa类HDAC的蛋白质亚类在调节神经元细胞死亡中的作用。基于本综述中提供的信息，很明显，尽管该蛋白质家族的成员在主要序列上非常相似，但它们在协调大脑中凋亡细胞死亡中通常具有不同的作用。

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