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Effects of levetiracetam monotherapy on the cognitive function of epilepsy patients

机译：左乙拉西坦单药对癫痫患者认知功能的影响

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Aims: To estimate the effect of levetiracetam (LEV) on cognitive function and mood status in newly diagnosed epilepsy patients. Methods: Fifty-five drug-na?ve epilepsy patients (M:F ratio = 31:24; mean age = 30.9 years) were included. All patients underwent two neuropsychological (NP) tests, one before receiving LEV and then another 12.9 ± 5.0 months after starting LEV monotherapy. We evaluated general cognitive function, verbal/visual attention and memory, linguistic and visuospatial functions, frontal lobe function, and mood status. Repeated-measures regression and generalized estimating equation models were applied to assess the effects of all the confounding variables such as seizure control, average LEV dose, duration of epilepsy, inter-test interval, and subtype of epilepsy syndrome. Results: LEV monotherapy over 1 year revealed significant improvements in the following domains of NP tests with the correction of possible confounding variables: verbal and visual attention, psychomotor speed, mental flexibility, executive function, verbal fluency and word generation. No NP domains showed any significant decrease. Conclusion: Our study suggested that LEV monotherapy had no harmful effect on cognitive function in drug-na?ve patients with epilepsy.
机译：目的：评估左乙拉西坦（LEV）对新诊断的癫痫患者认知功能和情绪状态的影响。方法：纳入55名初次接受药物治疗的癫痫患者（男：女比= 31:24;平均年龄= 30.9岁）。所有患者均接受了两次神经心理学（NP）测试，一次接受LEV治疗，另一次在开始LEV单一疗法后12.9±5.0个月。我们评估了一般的认知功能，言语/视觉注意力和记忆力，语言和视觉空间功能，额叶功能以及情绪状态。应用重复测量回归和广义估计方程模型评估所有混杂变量的影响，例如癫痫发作控制，平均LEV剂量，癫痫病持续时间，测试间隔和癫痫综合征的亚型。结果：LEV单药治疗超过1年显示出在NP测试的以下领域的显着改善，并纠正了可能造成混淆的变量：言语和视觉注意，心理运动速度，心理柔韧性，执行功能，言语流畅性和单词生成。没有NP域显示任何显着减少。结论：我们的研究表明，LEV单一疗法对初次使用药物的癫痫患者的认知功能无害。

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