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Differential gene expression in the respiratory tree of the sea cucumber Apostichopus japonicus during aestivation

机译：刺参海参培植过程中呼吸基因的差异基因表达

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摘要

Sea cucumbers, Apostichopus japonicus, experience seasonally high water temperatures during the summer months and enter aestivation to survive. Aestivation is characterized by strong metabolic rate depression which is supported by a series of strategies including reorganizing metabolic processes, suppressing cell functions, enhancing cytoprotective mechanisms, and altered gene expression. The respiratory tree tissue of the sea cucumber is an excellent material for studying aestivation, undergoing obvious atrophy during aestivation. The present study analyzed the global gene expression profile of respiratory tree tissue of A. japonicus during aestivation by constructing and screening three libraries representing key stages of aestivation: non-aestivation (NA), deep-aestivation (DA), and arousal from aestivation (M) using RNA-seq. A total of 1240, 1184 and 303 differentially expressed genes (DEGs) were identified following the criteria of [log(2) ratiol >= 1 and FDR <= 0.001 in comparisons of DA vs. NA, AA vs. NA and DA vs. AA. A set of respiratory tree specific DEGs was identified the first time and, in addition, common DEGs that were responsive to aestivation in both respiratory tree and intestine were identified. Functional analysis of DEGs was further performed by GO enrichment analysis and respiratory tree specific GO terms were screened out and provide interesting hints for further studies of the molecular regulation of aestivation in A. japonicus. (c) 2014 Elsevier B.V. All rights reserved.
机译：刺参（Apostichopus japonicus）在夏季会经历季节性的高水温，并开始吸水以维持生存。陶醉的特征是强烈的代谢率下降，这受到一系列策略的支持，这些策略包括重组代谢过程，抑制细胞功能，增强细胞保护机制和改变基因表达。海参的呼吸树组织是研究吸水的极好材料，在吸水期间会发生明显的萎缩。本研究通过构建和筛选代表着培养关键阶段的三个文库来分析日本洋蓟的呼吸树组织的全局基因表达谱：非培养（NA），深培养（DA）和因培养引起的觉醒（ M）使用RNA-seq。根据DA对NA，AA对NA和DA对ID的比较，按照[log（2）ratiol> = 1和FDR <= 0.001的标准，共鉴定了1240、1184和303个差异表达基因（DEG）。机管局。首次确定了一组呼吸树特有的DEG，此外，还确定了对呼吸树和肠道中的培养都敏感的常见DEG。通过GO富集分析进一步进行了DEG的功能分析，筛选出了呼吸树特有的GO术语，为进一步研究日本刺槐的分子调控提供了有趣的提示。 （c）2014 Elsevier B.V.保留所有权利。

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