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首页> 外文期刊>Marine genomics >Draft genome assemblies and predicted microRNA complements of the intertidal lophotrochozoans Patella vulgata (Mollusca, Patellogastropoda) and Spirobranchus (Pomatoceros) lamarcki (Annelida, Serpulida)
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Draft genome assemblies and predicted microRNA complements of the intertidal lophotrochozoans Patella vulgata (Mollusca, Patellogastropoda) and Spirobranchus (Pomatoceros) lamarcki (Annelida, Serpulida)

机译：潮间虫（Polella vulgata）（软体动物，Patellogastropoda）和Spirobranchus（Pomatoceros）lamarcki（Annelida，Serpulida）的基因组草案和预测的microRNA补充

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MicroRNAs (miRNA) are small non-coding RNAs that act post-transcriptionally to regulate gene expression levels. Some studies have indicated that microRNAs may have low homoplasy, and as a consequence the phylogenetic distribution of microRNA families has been used to study animal evolutionary relationships. Limited levels of lineage sampling, however, may distort such analyses. Lophotrochozoa is an under-sampled taxon that includes molluscs, annelids and nemerteans, among other phyla. Here, we present two novel draft genomes, those of the limpet Patella vulgate and polychaete Spirobranchus (Pomatoceros) lamarcki. Surveying these genomes for known microRNAs identifies numerous potential orthologues, including a number that have been considered to be confined to other lineages. RT-PCR demonstrates that some of these (miR-1285, miR-1287, miR-1957, miR-1983 and miR-3533), previously thought to be found only in vertebrates, are expressed. This study provides genomic resources for two lophotrochozoans and reveals patterns of microRNA evolution that could be hidden by more restricted sampling. (C) 2015 Elsevier B.V. All rights reserved.
机译：MicroRNA（miRNA）是小的非编码RNA，转录后起作用以调节基因表达水平。一些研究表明，microRNA的同质性可能较低，因此，microRNA家族的系统发育分布已用于研究动物进化关系。但是，有限的血统采样水平可能会使这种分析失真。地方风眼是一个采样不足的分类单元，包括软体动物，肢体动物和nemerteans等。在这里，我们介绍了两个新颖的基因组草图，即贝Pat和多毛Spi Spirobranchus（Pomatoceros）lamarcki的基因组。对这些基因组进行调查以获取已知的microRNA，可发现许多潜在的直向同源物，包括一些被认为仅限于其他谱系的直向同源物。 RT-PCR证实表达了其中一些（miR-1285，miR-1287，miR-1957，miR-1983和miR-3533），以前认为仅在脊椎动物中发现。这项研究提供了两种滋养体的基因组资源，并揭示了可能被更严格的采样所隐藏的microRNA进化模式。 （C）2015 Elsevier B.V.保留所有权利。

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