Characterisation of the coccolithovirus intein

Allen MJ; Lanzen A; Bratbak G

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Characterisation of the coccolithovirus intein

机译：球菌病毒内含子的表征

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The identification of inteins in viral genomes is becoming increasingly common. Inteins are selfish DNA elements found within coding regions of host proteins. Following translation, they catalyse their own excision and the formation of a peptide bond between the flanking protein regions. Many inteins also display homing endonuclease function. Here, the newly identified coccolithovirus intein is described and is predicted to have both self-splicing and homing endonuclease activity. The biochemical mechanism of its protein splicing activity is hypothesised, and the prevalence of the intein among natural coccolithovirus isolates is tested.

机译：病毒基因组中内含肽的鉴定变得越来越普遍。内含蛋白是在宿主蛋白的编码区内发现的自私的DNA元素。翻译后，它们催化自己的切除并在侧翼蛋白质区域之间形成肽键。许多内含肽还显示归巢核酸内切酶功能。在这里，描述了新鉴定的cococothothovirus intein，并预测其具有自剪接和归巢核酸内切酶活性。假设其蛋白剪接活性的生化机制，并测试了天然球菌病毒分离物中intein的普遍性。

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《Marine genomics》 |2011年第1期|共7页
作者
Allen MJ; Lanzen A; Bratbak G;
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正文语种 eng
中图分类遗传学;
关键词
Intein; Homing endonuclease; Coccolithovirus; Virus; Marine; Evolution;

机译：内含肽;归巢核酸内切酶;球菌病毒;病毒;海洋;进化;

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专利

1. Characterisation of the coccolithovirus intein [J] . Allen MJ, Lanzen A, Bratbak G Marine genomics . 2011,第1期

机译：球菌病毒内含子的表征
2. Engineering Artificially Split Inteins for Applications in Protein Chemistry: Biochemical Characterization of the Split Ssp DnaB Intein and Comparison to the Split Sce VMA Intein [J] . Steffen Brenzel, Thomas Kurpiers, Henning D.Mootz Biochemistry . 2006,第6期

机译：工程化的人工拆分蛋白在蛋白质化学中的应用：拆分的Ssp DnaB蛋白质的生化特征和与拆分的Sce VMA蛋白质的比较
3. Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis [J] . Josef A Gramespacher, Adam J. Stevens, Duy P. Nguyen, Journal of the American Chemical Society . 2017,第24期

机译：内含肽同源物：通过有针对性的蛋白水解的有条件的组装和分裂的内含肽的剪接。
4. Protein Trans-splicing Activities of Multiple Split Inteins Derived from Ssp GyrB Intein [C] . Song Huiling, Meng Qing, Liu Xiang-Qin Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on . 2012

机译：来自Ssp GyrB内含子的多个分裂内含子的蛋白质反式分裂活性。
5. High Throughput Engineering Of Split Intein With Improved Trans-Splicing Kinetics And Novel Split Intein Mediated Modular Synthesis. [D] . Li, Naiyi. 2014

机译：具有改进的反式剪接动力学和新型拆分内含蛋白介导的模块合成的拆分内含蛋白的高通量工程。
6. Mini-Intein Structures from Extremophiles Suggest a Strategy for Finding Novel Robust Inteins [O] . Mimmu K. Hiltunen, Hannes M. Beyer, Hideo Iwaï 2021

机译：Exprootophiles的迷你intein结构表明了一种寻找新颖强大inteins的策略
7. The crystal structure of the naturally split gp41-1 intein guides the engineering of orthogonal split inteins from a cis-splicing intein [O] . Hannes M. Beyer, Kornelia M. Mikula, Mi Li, 2019

机译：自然分裂GP41-1 Intein的晶体结构引导了顺式剪接内含膜的正交分裂内嵌入工程

Characterisation of the coccolithovirus intein

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