Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation.

Oi Hiroshi; Matsuura Daisuke; Miyake MasamiUeno MasamitiTakai IzumiYamamoto TakeshiKubo MasayoshiMoss JoelNoda Masatoshi

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Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation.

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Kampo formulations are traditional herbal medications used in China and Japan for many centuries to treat diarrheal diseases such as cholera. Our studies were undertaken to identify and verify by chemical synthesis the active components that inhibited cholera toxin (CT), the virulence factor secreted by Vibrio cholerae, the causative agent of cholera. The Kampo formulation, Daio-kanzo-to, inhibited CT activities (i.e., ADP-ribosylation, Chinese hamster ovary cell elongation); in Daio-kanzo-to, Daio (Rhei rhizoma) was responsible for this effect. Among several components purified from Daio extract, rhubarb galloyl-tannin, a compound characterized by a polygallate structure, was the most effective. To define the active component, gallate analogues similar to rhubarb galloyl-tannin were synthesized. These gallate compounds inhibited all CT activities including ADP-ribosylation, elongation of Chinese hamster ovary cells, and importantly, fluid accumulation in ileal loops. Thus, Kampo formulations or their gallate components might be effective adjunctive therapy with oral rehydration solution for the severe diarrhea of cholera.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2002年第5期|3042-3046|共5页
作者
Oi Hiroshi; Matsuura Daisuke; Miyake MasamiUeno MasamitiTakai IzumiYamamoto TakeshiKubo MasayoshiMoss JoelNoda Masatoshi;
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作者单位

Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.;

ublic.wh.hb.cn;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Cholera Toxin; Drugs; Chinese Herbal; Gallic Acid; Medicine; Kampo; Tannins; 霍乱毒素; 中草药; 没食子酸; 单宁类;

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Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation.

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