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首页> 外文期刊>Canadian journal of gastroenterology >Optical biopsy using tissue spectroscopy and optical coherence tomography.
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Optical biopsy using tissue spectroscopy and optical coherence tomography.

机译：使用组织光谱学和光学相干断层扫描进行光学活检。

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摘要

'Optical biopsy' or 'optical diagnostics' is a technique whereby light energy is used to obtain information about the structure and function of tissues without disrupting them. In fluorescence spectroscopy, light energy (usually provided by a laser) is used to excite tissues and the resulting fluorescence provides information about the target tissue. Its major gastrointestinal application has been in the evaluation of colonic polyps, in which it can reliably distinguish malignant from benign lesions. Optical coherence tomography (OCT) has been used in the investigation of Barrett's epithelium (and dysplasia), although a variety of other applications are feasible. For example, OCT could assist in the identification and staging of mucosal and submucosal neoplasms, the grading of inflammation in the stomach and intestine, the diagnosis of biliary tumours and the assessment of villous architecture. OCT differs from endoscopic ultrasound, a complementary modality, in that it has a much higher resolution butlesser depth of penetration. The images correlate with the histopathological appearance of tissues, and the addition of Doppler methods may enable it to evaluate the vascularity of tumours and the amount of blood flow in varices. Refinements in these new optical techniques will likely make them valuable in clinical practice, although their specific roles have yet to be determined.
机译：“光学活检”或“光学诊断”是一种使用光能来获取有关组织的结构和功能的信息而不会破坏它们的技术。在荧光光谱中，光能（通常由激光提供）用于激发组织，并且所产生的荧光提供有关目标组织的信息。它的主要胃肠道应用是在结肠息肉的评估中，它可以可靠地区分恶性和良性病变。光学相干断层扫描（OCT）已用于Barrett上皮（和发育异常）的研究，尽管许多其他应用也是可行的。例如，OCT可以协助粘膜和粘膜下肿瘤的鉴定和分期，胃和肠的炎症分级，胆道肿瘤的诊断以及绒毛结构的评估。 OCT与内窥镜超声（一种互补形式）不同，它具有更高的分辨率，但穿透深度更小。这些图像与组织的组织病理学外观相关，多普勒方法的添加可能使它能够评估肿瘤的血管性和静脉曲张中的血流量。尽管尚未确定具体的作用，但对这些新的光学技术的改进可能会使其在临床实践中有价值。

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