Mechanochemical Synthesis of Nanocomposites of Drugs with Inorganic Oxides

T. P. Shakhtshneider; S. A. Myz; M. A. Mikhailenko

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Mechanochemical Synthesis of Nanocomposites of Drugs with Inorganic Oxides

机译：无机氧化物药物纳米复合物的机械化学合成

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The nanocomposites of piroxicam and indomethacin with fine porous inorganic oxides, alumina, silica, and magnesia, were obtained by high energy ball milling. Except for the piroxicam-alumina system, the composites revealed higher dissolution rate and solubility of the drugs as compared to the initial ones. The changes in the IR spectra suggested the interaction of the components during ball milling. It was assumed that the formation of new bonds at the contacts of particles in the composite resulted in stabilization of drugs in a metastable state inhibiting their transition into the initial crystalline form.

机译：通过高能球磨获得了吡罗昔康和吲哚美辛与多孔无机氧化物，氧化铝，二氧化硅和氧化镁的纳米复合材料。除了吡罗昔康-氧化铝体系外，与最初的复合物相比，该复合物显示出更高的药物溶解速度和溶解度。红外光谱的变化表明了球磨过程中各组分之间的相互作用。假定在复合材料中的颗粒接触处形成新的键会导致药物稳定在亚稳态，从而抑制了它们转变为初始晶体形式。

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《Materials and Manufacturing Processes》 |2009年第12期|共8页
作者
T. P. Shakhtshneider; S. A. Myz; M. A. Mikhailenko;
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正文语种 eng
中图分类工程材料学;
关键词
Alumina; Ball milling; Indomethacin; Magnesia; Nanocomposite; Piroxicam; Silica.;

机译：氧化铝;球磨;消炎痛;氧化镁;纳米复合材料;吡罗昔康;二氧化硅;

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1. Mechanochemical Synthesis of Nanocomposites of Drugs with Inorganic Oxides [J] . T. P. Shakhtshneider, S. A. Myz, M. A. Mikhailenko Materials and Manufacturing Processes . 2009,第10a12期

机译：无机氧化物药物纳米复合物的机械化学合成
2. Mechanochemical Synthesis of Iron and Cobalt Magnetic Metal Nanoparticles and Iron/Calcium Oxide and Cobalt/Calcium Oxide Nanocomposites [J] . Dr. Varun Chaudhary, Yaoying Zhong, Dr. Harshida Parmar, ChemistryOpen . 2018,第8期

机译：机械化学合成铁和钴磁性金属纳米粒子以及铁/氧化钙和钴/氧化钙纳米复合材料
3. Solvent-free mechanochemical synthesis of graphene oxide and Fe3O4-reduced graphene oxide nanocomposites for sensitive detection of nitrite [J] . Bharath G., Madhu Rajesh, Chen Shen-Ming, Journal of Materials Chemistry, A. Materials for energy and sustainability . 2015,第30期

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4. Ni-YSZ Nanocomposite Synthesis: Mechanochemical vs Novel Sol-Gel Method for Solid Oxide Electrolysers [C] . Manuel Ojeda, Tianyu Zhao, Huizhi Wang International Conference on Applied Energy . 2018

机译：Ni-ysz纳米复合材料合成：用于固体氧化物电解器的机械化学Vs新型溶胶 - 凝胶方法
5. Thermo-mechanochemical-synthesis of novel nanocomposites for superior physical and chemical properties. [D] . Deore, Suraj Waman. 2002

机译：新型纳米复合材料的热机械化学合成，具有出色的物理和化学特性。
6. Mechanochemical Synthesis of Iron and Cobalt Magnetic Metal Nanoparticles and Iron/Calcium Oxide and Cobalt/Calcium Oxide Nanocomposites [O] . Dr. Varun Chaudhary, Yaoying Zhong, Dr. Harshida Parmar, 2018

机译：铁钴金属磁性纳米粒子及铁/氧化钙和钴/氧化钙纳米复合材料的机械化学合成
7. Mechanochemical Synthesis of TiO2 Nanocomposites as Photocatalysts for Benzyl Alcohol Photo-Oxidation [O] . Weiyi Ouyang, Ewelina Kuna, Alfonso Yepez, 2016

机译：TiO2纳米复合材料的机械化学合成作为苄醇光氧化光催化剂
8. Nanocomposite/Hybrid Materials of Electroactive Polymers With Inorganic Oxides for Biosensor Applications [R] . Wei, Y. 2001

机译：用于生物传感器应用的具有无机氧化物的电活性聚合物的纳米复合材料/杂化材料

Mechanochemical Synthesis of Nanocomposites of Drugs with Inorganic Oxides

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