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Bioactivity Improvement of Forsterite-Based Scaffolds with nano-58S Bioactive Glass

机译：纳米58S生物活性玻璃改善镁橄榄石基支架的生物活性

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摘要

Forsterite-based composite scaffolds with interconnected pore architecture were successfully manufactured via selective laser sintering. The nano-58S bioactive glass (BG) was added to forsterite for purpose of improving the bioactivity of the composite scaffolds. The effect of nano-58S BG contents on the biological behavior and mechanical properties was investigated. The results showed that the composite scaffolds could induce the formation of apatite compared with the pure forsterite scaffolds. Moreover, with increasing nano-58S BG, the scattered spherical apatite particles accumulated continuously and covered the whole surface. At last the apatite layer became sponge-like shape. The presence of apatite was confirmed with scanning electron microscopy equipped with energy dispersive spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy. In addition, MG-63 cells adhesion was enhanced with increase in the amount of the nano-58S BG. Besides, the maximum compressive strength was 43.9 ± 1.1 MPa when the nano-58S BG was 20.0 wt%. This study indicated that the composite scaffolds have a potential for bone tissue engineering.
机译：通过选择性激光烧结成功地制造了具有连通孔结构的基于镁橄榄石的复合支架。为了改善复合支架的生物活性，将纳米58S生物活性玻璃（BG）加入镁橄榄石中。研究了纳米58S BG含量对生物学行为和力学性能的影响。结果表明，与纯镁橄榄石支架相比，复合支架可以诱导磷灰石的形成。而且，随着纳米58S BG的增加，散布的球形磷灰石颗粒不断积累并覆盖了整个表面。最后，磷灰石层变成海绵状。磷灰石的存在通过配备有能量色散光谱仪，X射线衍射和傅里叶变换红外光谱仪的扫描电子显微镜确认。另外，随着纳米58S BG含量的增加，MG-63细胞的粘附性增强。此外，当纳米58S BG为20.0重量％时，最大压缩强度为43.9±1.1MPa。这项研究表明复合支架具有骨组织工程的潜力。

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