What controls the expression of the core-1 (Thomsen-Friedenreich) glycotope on tumor cells?

Karsten U.; Goletz S.

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What controls the expression of the core-1 (Thomsen-Friedenreich) glycotope on tumor cells?

机译：什么控制了肿瘤细胞上core-1（Thomsen-Friedenreich）糖基的表达？

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Malignant transformation is tightly connected with changes in the glycosylation of proteins and lipids, which in turn are contributing to the invasive and metastatic behavior of tumor cells. One example of such changes is demasking of the otherwise hidden core-1 structure, also known as Thomsen-Friedenreich antigen, which is a highly tumor-specific glycotope and potentially a cancer stem cell marker. This review summarizes what is known about the mechanism(s) of its expression on tumor cells. New data reveal a close connection between tumor metabolism and Golgi function. Based on these data, we suggest that the expression of this antigen is also a marker of aerobic glycolysis.

机译：恶性转化与蛋白质和脂质糖基化的变化紧密相关，这反过来又有助于肿瘤细胞的侵袭和转移行为。此类变化的一个例子是对原本隐藏的core-1结构（也称为Thomsen-Friedenreich抗原）进行掩盖，这是一种高度肿瘤特异性糖基，并且可能是癌症干细胞标记。这篇综述总结了在肿瘤细胞上表达的机制。新数据揭示了肿瘤代谢与高尔基体功能之间的紧密联系。基于这些数据，我们建议该抗原的表达也是有氧糖酵解的标志。

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《Biochemistry》 |2015年第7期|共7页
作者
Karsten U.; Goletz S.;
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正文语种 eng
中图分类生物化学;
关键词
glycosylation; Golgi; core-1; Thomsen-Friedenreich; glycolysis; tumor metabolism; pH;

机译：糖基化;高尔基;core-1;Thomsen-Friedenreich;糖酵解;肿瘤代谢;pH;

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1. 大肠侧向发育型肿瘤细胞株ADP-核糖基化因子1的表达及其意义 [J] . 马文敏, 姜泊, 赖卓胜, 癌症（英文版） . 2005,第006期
2. What controls the expression of the core-1 (Thomsen-Friedenreich) glycotope on tumor cells? [J] . Karsten U., Goletz S. Biochemistry . 2015,第7期

机译：什么控制了肿瘤细胞上core-1（Thomsen-Friedenreich）糖基的表达？
3. Characterisation of disseminated tumor cells in the bone marrow of breast cancer patients by the Thomsen-Friedenreich tumor antigen. [J] . Schindlbeck C, Jeschke U, Schulze S, Histochemistry and cell biology . 2005,第6期

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7. Expression of CD176 (Thomsen-Friedenreich antigen) on lung breast and liver cancer-initiating cells [O] . Wei-Ming Lin, Uwe Karsten, Steffen Goletz, 2011

机译：CD176（Thomsen-Friedenreich抗原）在肺癌乳腺癌和肝癌起始细胞中的表达
8. Differentiation-related expression of the Thomsen-Friedenreich glycotope in developing human lung and in lung carcinoma [O] . Valeriu Toma, Tetsutaro Sata, Peter Vogt, 1999

机译：在肺癌和肺癌中发展硫豆葡萄糖糖蛋白的差异化相关表达
9. Differentiation, early response gene expression, and apoptosis induction in human breast tumor cells by Okadaic Acid and related inhibitors of protein phosphatases 1 and 2A. Okadaic acid effects on human breast tumor cells [R] . Kiguchi, K. , Giometti, C. , Chubb, C. H. , 1992

机译：冈田酸和蛋白磷酸酶1和2a的相关抑制剂在人乳腺肿瘤细胞中的分化，早期反应基因表达和凋亡诱导。冈田酸对人乳腺癌细胞的影响

What controls the expression of the core-1 (Thomsen-Friedenreich) glycotope on tumor cells?

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