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Carbonyl Stress in Bacteria: Causes and Consequences

机译：细菌中的羰基应激：原因和后果

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摘要

Pathways of synthesis of the alpha-reactive carbonyl compound methylglyoxal (MG) in prokaryotes are described in this review. Accumulation of MG leads to development of carbonyl stress. Some pathways of MG formation are similar for both pro- and eukaryotes, but there are reactions specific for prokaryotes, e.g. the methylglyoxal synthase reaction. This reaction and the glyoxalase system constitute an alternative pathway of glucose catabolism-the MG shunt not associated with the synthesis of ATP. In violation of the regulation of metabolism, the cell uses MG shunt as well as other glycolysis shunting pathways and futile cycles enabling stabilization of its energetic status. MG was first examined as a biologically active metabolic factor participating in the formation of phenotypic polymorphism and hyperpersistent potential of bacterial populations. The study of carbonyl stress is interesting for evolutionary biology and can be useful for constructing highly effective producer strains.
机译：这篇综述描述了原核生物中α-反应性羰基化合物甲基乙二醛（MG）的合成途径。 MG的积累导致羰基应力的发展。 MG形成的某些途径对于原核生物和真核生物都是相似的，但是存在对原核生物特异的反应，例如。甲基乙二醛合酶反应。该反应和乙二醛酶系统构成了葡萄糖分解代谢的另一种途径-与ATP的合成无关的MG分流器。该细胞违反了新陈代谢的规定，使用了MG分流以及其他糖酵解分流途径和无效循环，从而使其能量状态得以稳定。 MG首先被作为参与表型多态性和细菌种群超持久潜力形成的生物活性代谢因子进行了研究。羰基胁迫的研究对于进化生物学很有意义，并且对构建高效生产菌株很有用。

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