Cytotoxic Signal Transmission Pathways via TNF Family Receptors

I.P.Beletsky; A.B.Moshnikova; O.V.Prusakova

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Cytotoxic Signal Transmission Pathways via TNF Family Receptors

机译：通过TNF家族受体的细胞毒性信号传递途径

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Studies indicating an important role of the TNF-receptor family in control of cell proliferation, differentiation, and death have drastically increased in number in recent years. The main function of many members of this family is cell death triggering, and this is apparently the only function for some of them. Studies on the molecular mechanisms of cell death activated by members of the TNF-receptor family revealed and identified proteins directly or indirectly associated with TNF receptors. Pathways of cytotoxic signal transduction by some members of the TNF-Rs family based on currently proven protein-protein interactions and the role of distinct proteins in these processes are summarized in this review.

机译：近年来，研究表明TNF受体家族在控制细胞增殖，分化和死亡中的重要作用已急剧增加。该家族许多成员的主要功能是触发细胞死亡，这显然是其中某些成员的唯一功能。对由TNF受体家族成员激活的细胞死亡的分子机制的研究揭示并鉴定了与TNF受体直接或间接相关的蛋白质。这篇综述总结了基于目前已证明的蛋白质-蛋白质相互作用以及不同蛋白质在这些过程中的作用而导致的TNF-Rs家族某些成员进行细胞毒性信号转导的途径。

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来源
《Biochemistry》 |2002年第3期|共17页
作者
I.P.Beletsky; A.B.Moshnikova; O.V.Prusakova;
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正文语种 eng
中图分类生物化学;
关键词
apoptosis; TNF-receptor family; tumor necrosis factor; TNF-RI; TNF-RII; fas-ligand; fas-antigen; caspases; bcl-2 protein family;

机译：细胞凋亡;TNF受体家族;肿瘤坏死因子;TNF-RI;TNF-RII;fas配体;fas抗原;胱天蛋白酶;bcl-2蛋白家族;

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专利

1. Cytotoxic Signal Transmission Pathways via TNF Family Receptors [J] . I.P.Beletsky, A.B.Moshnikova, O.V.Prusakova Biochemistry . 2002,第3期

机译：通过TNF家族受体的细胞毒性信号传递途径
2. Death receptor 5-mediated TNFR family signaling pathways modulate gamma-humulene-induced apoptosis in human colorectal cancer HT29 cells. [J] . Lan YH, Wu YC, Wu KW, Oncology reports . 2011,第2期

机译：死亡受体5介导的TNFR家族信号通路调节人大肠癌HT29细胞中γ-humulene诱导的细胞凋亡。
3. Signaling pathways mediated by the TNF- and cytokine-receptor families target a common cis-element of the IFN regulatory factor 1 promoter. [J] . Gupta S, Xia D, Jiang M, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第11期

机译：由TNF和细胞因子受体家族介导的信号通路靶向IFN调节因子1启动子的常见顺式元件。
4. Functions of new members of the human tumor necrosis factor receptor (TNFR) superfamily [C] . Byungsuk Kwon, Byung-S. Youn . 1999

机译：人类肿瘤坏死因子受体（TNFR）超家族新成员的功能
5. Signaling through CD28 family receptors: An analysis of CD80- and CD86-dependent pathways. [D] . Slavik, Jacqueline Marie. 1998

机译：通过CD28家族受体发出信号：对CD80和CD86依赖性途径的分析。
6. Structural commonality of C1q TNF‐related proteins and their potential to activate relaxin/insulin‐like family peptide receptor 1 signalling pathways in cancer cells [O] . Thomas Klonisch, Aleksandra Glogowska, Thatchawan Thanasupawat, 2017

机译：C1q TNF相关蛋白的结构共性及其激活癌细胞中松弛素/胰岛素样家族肽受体1信号通路的潜力
7. Structural commonality of C1q TNF‐related proteins and their potential to activate relaxin/insulin‐like family peptide receptor 1 signalling pathways in cancer cells [O] . Thomas Klonisch, Aleksandra Glogowska, Thatchawan Thanasupawat, 2016

机译：C1Q TNF相关蛋白质的结构共性及其激活松弛素/胰岛素样肽受体1信号传导途径的潜力
8. EgF Receptor Mabs and Chemotherapy/Characterization of Synergistic Interactions Between Cytotoxic Agents and Inhibitors of the Tyrosine Kinase Growth Factor Receptor Signalling Cascade [R] . Seidman, A. D. 1998

机译：EgF受体单克隆抗体和化疗/表征细胞毒性剂和酪氨酸激酶生长因子受体信号级联抑制剂之间协同作用的相互作用

Cytotoxic Signal Transmission Pathways via TNF Family Receptors

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