Study of Antiproteinase Activity of Acylated Derivatives of Bowman-Birk Soybean Proteinase Inhibitor

E.V.Malykh; N.I.Larionova

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Study of Antiproteinase Activity of Acylated Derivatives of Bowman-Birk Soybean Proteinase Inhibitor

机译：Bowman-Birk大豆蛋白酶抑制剂的酰化衍生物抗蛋白酶活性的研究

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The effect of acylation of Bowman-Birk soybean proteinase inhibitor (BBI) by derivatives of various unsaturated fatty acids on inhibition of trypsin, alpha-chymotrypsin, and human leukocyte elastase was inestigated. Inhibition (K_i) and kinetic (k_ass, k_diss) constants of interaction between proteases and acylated BBI derivatives were determined. For mono-, di-, and triacylated BBI derivatives, insertion of two oleic residues into the BBI molecule was demonstrated to be more potent for exhibiting antiproteinase activity.

机译：研究了各种不饱和脂肪酸衍生物对Bowman-Birk大豆蛋白酶抑制剂（BBI）的酰化作用对胰蛋白酶，α-胰凝乳蛋白酶和人白细胞弹性蛋白酶的抑制作用。确定了蛋白酶和酰化的BBI衍生物之间相互作用的抑制常数（K_i）和动力学常数（k_ass，k_diss）。对于单，二和三酰化的BBI衍生物，两个油性残基插入BBI分子被证明对展现抗蛋白酶活性更有效。

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《Biochemistry》 |2002年第12期|共5页
作者
E.V.Malykh; N.I.Larionova;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
bowman-birk inhibitor; acylation; unsaturated fatty acids; inhibition constant; trypsin; alpha-chymotrypsin; human leukocyte elastase;

机译：Bowman-Birk抑制剂;酰化作用;不饱和脂肪酸;抑制常数;胰蛋白酶;α-胰凝乳蛋白酶;人白细胞弹性蛋白酶;

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1. Study of Antiproteinase Activity of Acylated Derivatives of Bowman-Birk Soybean Proteinase Inhibitor [J] . E.V.Malykh, N.I.Larionova Biochemistry . 2002,第12期

机译：Bowman-Birk大豆蛋白酶抑制剂的酰化衍生物抗蛋白酶活性的研究
2. Novel alleles among soybean Bowman-Birk proteinase inhibitor gene families. [J] . Wang Y, Chen X, Qiu L Science in China, Series C. Life science . 2008,第8期

机译：大豆Bowman-Birk蛋白酶抑制剂基因家族中的新等位基因。
3. The Interaction Between Duodenase, Proteinase with Double Specificity and soybean Inhibitors of Bowman-Birk and Kunitz Type [J] . Gladysheva I.P., Zamolodchikova T.S., Sokolova E.A. Биохимия . 1999,第11期

机译：弓形酶，双重特异性蛋白酶和Bowman-Birk和Kunitz型大豆抑制剂之间的相互作用
4. Study on the Endogenous Proteinase of Specially Inactivating Trypsin Inhibitors in Soybeans [C] . Guo Ling, Huo Guicheng MOST-USDA Workshop on Agricultural Products Processing and Food Safety; 20050921-24; Beijing(CN) . 2005

机译：大豆中特殊失活胰蛋白酶抑制剂的内源蛋白酶研究
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Nucleotide sequence of a cDNA encoding soybean Bowman-Birk proteinase inhibitor. [O] . J M Baek, S I Kim 1993

机译：编码大豆Bowman-Birk蛋白酶抑制剂的cDNA的核苷酸序列。
7. Retardation by the soybean Bowman-Birk inhibitor of elastin hydrolysis catalyzed by leukocyte proteinases [O] . Tikhonova Tamara V., Gladysheva Inna P., Larionova Natalia I. 1995

机译：大豆Bowman-Birk抑制剂对白细胞蛋白酶催化的弹性蛋白水解的阻滞作用
8. Structure-Function Relationships of Proteinase from Soybean (Bowman-Birk) and Lima Bean: Modification by N-Acetylimidazole [R] . Kay, E. 1978

机译：大豆（Bowman-Birk）和利马豆蛋白酶的结构 - 功能关系：N-乙酰基咪唑的修饰

Study of Antiproteinase Activity of Acylated Derivatives of Bowman-Birk Soybean Proteinase Inhibitor

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