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首页> 外文期刊>Cancer epidemiology >Colorectal cancer risk and dyslipidemia: A case-cohort study nested in an Italian multicentre cohort
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Colorectal cancer risk and dyslipidemia: A case-cohort study nested in an Italian multicentre cohort

机译：大肠癌的风险和血脂异常：一项病例研究，嵌套在一个意大利多中心队列中

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Background: Dyslipidemia is an established risk factor for many diseases, but its effect on colorectal cancer risk is less clear. We investigated the association of colorectal cancer risk with plasma triglycerides, total, HDL, and LDL cholesterol in four Italian EPIC centers. Methods: We conducted a case-cohort study on participants recruited to four Italian EPIC centers (Turin, Varese, Naples, and Ragusa; 34,148 subjects). A random subcohort of 850 subjects was obtained and 286 colorectal cancer cases were diagnosed. Triglycerides, total and HDL cholesterol were determined in plasma samples obtained at baseline and stored at -196. °C; LDL cholesterol was calculated. Hazard ratios (HR) with 95% confidence intervals (CI), adjusted for potential confounders, were estimated by Cox regression models using the Prentice method. Results: The highest tertiles of total (HR 1.66, 95%CI 1.12-2.45) and LDL cholesterol (HR 1.87, 95%CI 1.27-2.76) were associated with increased colorectal cancer risk compared to lowest tertiles. Risks were greater for men than women, and for postmenopausal than premenopausal women. Highest tertiles of total and LDL cholesterol were also significantly associated with increased risks of colon cancer, distal colon cancer, and rectal cancer, but not proximal colon cancer. Conclusions: Our findings suggest that high levels of total and LDL cholesterol increase colorectal cancer risk, particularly in men and postmenopausal women. However additional studies are needed to clarify the role of plasma lipids in these cancers, particularly in view of the conflicting findings of previous studies.
机译：背景：血脂异常是许多疾病的既定危险因素，但对大肠癌风险的影响尚不清楚。我们在意大利的四个EPIC中心调查了大肠癌风险与血浆甘油三酸酯，总胆固醇，HDL和LDL胆固醇的关系。方法：我们对招募到四个意大利EPIC中心（都灵，瓦雷泽，那不勒斯和拉古萨; 34,148名受试者）的参与者进行了案例研究。获得了850名受试者的随机亚组，并诊断出286名结直肠癌病例。测定在基线时获得的血浆样品中的甘油三酸酯，总胆固醇和HDL胆固醇，并储存在-196。 °C;计算LDL胆固醇。使用Prentice方法通过Cox回归模型估算了针对潜在混杂因素进行调整的，具有95％置信区间（CI）的危险比（HR）。结果：与最低的三分位数相比，总的最高三分位数（HR 1.66，95％CI 1.12-2.45）和LDL胆固醇（HR 1.87，95％CI 1.27-2.76）与大肠癌风险增加相关。男性的风险大于女性，绝经后的风险大于绝经前的女性。总胆固醇和LDL胆固醇最高的三分位数也与结肠癌，远端结肠癌和直肠癌（而非近端结肠癌）风险增加显着相关。结论：我们的研究结果表明，高水平的总胆固醇和LDL胆固醇会增加结直肠癌的风险，尤其是在男性和绝经后女性中。但是，需要进一步的研究来阐明血浆脂质在这些癌症中的作用，尤其是考虑到先前研究的矛盾发现。

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