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首页> 外文期刊>Cancer epidemiology >Prevalence of human papillomavirus infection among young women in North India
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Prevalence of human papillomavirus infection among young women in North India

机译：印度北部年轻女性中人乳头瘤病毒感染的患病率

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Background: The number of women infected with human papillomavirus (HPV) and the distribution of the HPV genotypes vary across populations and with age. Objective: To determine the prevalence and genotype distribution of HPV in young married women aged 16-24 years. Methods: 1300 women residing in an urban slum in Delhi-donated samples of exfoliated cervical cells that were collected by the Digene kit and tested for the presence of HPV DNA by two techniques in parallel, i.e., PCR using PGMY consensus primers for all HPV types and the Digene HPV test (Hybrid Capture 2 (HC2) Probe B for high-risk (hr) types. Genotyping was done on all HPV positive samples using the Roche reverse line blot assay. Results: HPV infection was detected in 91/1300 (7%) samples by PCR and 110/1300 (8.4%) samples by HC2. Genotyping identified 20 high-risk and 11 low-risk types. HPV16 was the commonest high-risk type (3%) followed by HPV52 (1.2%) and HPV51 (0.8%). Among low-risk types, HPV62 was the commonest (0.8%), followed by HPV84 and HPV89 (0.5% each). Multiple infections were found in 3% of the HPV positive samples. Conclusion: A wide spectrum of HPV genotypes is seen in this young population. Knowledge about HPV types prevalent in communities in different regions of India would be useful in devising the optimum strategy for cervical cancer prevention. (C) 2010 Elsevier Ltd. All rights reserved.
机译：背景：感染人乳头瘤病毒（HPV）的妇女人数和HPV基因型的分布因人群和年龄而异。目的：确定16-24岁的已婚妇女中HPV的患病率和基因型分布。方法：1300名居住在德里的城市贫民窟的妇女捐献了脱落的宫颈细胞样本，该样本通过Digene试剂盒收集，并通过两种技术并行检测了HPV DNA的存在，即使用PGMY共有引物对所有HPV类型进行PCR高危（hr）类型的Digene HPV测试（Hybrid Capture 2（HC2）探针B。使用罗氏反向线印迹法对所有HPV阳性样品进行基因分型。结果：在91/1300（ PCR样本的7％）和HC2样本的110/1300的样本（8.4％），基因分型确定了20种高风险类型和11种低风险类型，HPV16是最常见的高风险类型（3％），其次是HPV52（1.2％）在低风险类型中，HPV62是最常见的（0.8％），其次是HPV84和HPV89（各为0.5％），在3％的HPV阳性样本中发现了多次感染。在这个年轻人口中发现了HPV基因型的谱图。 ndia将有助于制定预防子宫颈癌的最佳策略。 （C）2010 Elsevier Ltd.保留所有权利。

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