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首页> 外文期刊>Cancer epidemiology >Comparison of HPV genotypes and viral load between different sites of genital tract: The significance for cervical cancer screening
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Comparison of HPV genotypes and viral load between different sites of genital tract: The significance for cervical cancer screening

机译：生殖道不同部位HPV基因型和病毒载量的比较：宫颈癌筛查的意义

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Objectives: To compare the consistency of HPV genotype and viral loads among different sites within the female genital tract, and to correlate these with clinical outcomes. Methods: 2646 previously unscreened rural women were enrolled in this population-based, cross-sectional study between May 2006 and April 2007. Physician-collected samples from lower vagina, upper vagina, cervix, and one self-collected sample were taken from each woman. Viral load was assessed by HC2 using the relative light unit/cutoff ratio (RLU/CO), and HPV genotyping was tested by Linear Array. Results: The low risk HPV positive rate was highest in lower vagina samples and lowest in cervix samples. Overall kappa values of high risk HPV types between various anatomic sampling sites showed substantial or almost perfect agreement among women with normal pathology, CIN1, and CIN2+. In the CIN2+ population, high risk HPV viral load for cervix samples (557.25. RLU/CO) were much higher than upper vagina samples (96.43. RLU/CO, P<. 0.001), lower vagina samples (36.51. RLU/CO, P<. 0.001), and self-collected (206.83. RLU/CO, P= 0.003) samples. Conclusions: Although the distribution of high risk HPV genotypes was fairly equivalent across different genital sites, particularly for CIN2+ lesions, viral loads were largely variable. The findings may affect the cervical cancer screening methods using self-collected samples, particularly in resource-challenged areas.
机译：目的：比较女性生殖道内不同部位HPV基因型和病毒载量的一致性，并将其与临床结果相关联。方法：2006年5月至2007年4月之间，本人群为基础的横断面研究纳入了2646名以前未接受筛查的农村妇女。医师从每位妇女的下阴道，上阴道，子宫颈和一名自我收集的样本中采集了样本。 。使用相对光单位/截止比（RLU / CO）通过HC2评估病毒载量，并通过Linear Array测试HPV基因型。结果：低风险HPV阳性率在较低的阴道样本中最高，而在子宫颈样本中最低。在具有正常病理，CIN1和CIN2 +的女性中，不同解剖采样部位之间的高危HPV类型的总体kappa值显示出基本或几乎完美的一致性。在CIN2 +人群中，子宫颈样品的高危HPV病毒载量（557.25。RLU / CO）远高于上阴道样品（96.43。RLU / CO，P <.0.001），下阴道样品（36.51。RLU / CO， P <.0.001），并自行收集（206.83。RLU / CO，P = 0.003）样本。结论：尽管高风险HPV基因型在不同生殖器部位的分布相当，特别是对于CIN2 +病变，但病毒载量变化很大。这些发现可能会影响使用自我收集的样本进行子宫颈癌的筛查方法，特别是在资源匮乏的地区。

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