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首页> 外文期刊>Mayo Clinic Proceedings >Leisure-Time Screen-Based Sedentary Behavior and Leukocyte Telomere Length: Implications for a New Leisure-Time Screen-Based Sedentary Behavior Mechanism
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Leisure-Time Screen-Based Sedentary Behavior and Leukocyte Telomere Length: Implications for a New Leisure-Time Screen-Based Sedentary Behavior Mechanism

机译：基于休闲时间屏幕的久坐行为和白细胞端粒长度：对一种新的基于休闲时间屏幕的久坐行为机制的启示

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The field of sedentary behavior epidemiology is emerging. Short leukocyte telomere length (LTL) is a hallmark characteristic of aging, but LTL is also associated with morbidity and mortality independent of age. To my knowledge, only one study has examined the association between sedentary behavior and LTL. The purpose of this study was to examine the association between screen-based sedentary behavior and LTL. Data from the 1999-2002 National Health and Nutrition Examination Survey were used (N=6405; age, 20-84 years). Leisuretime screen-based sedentary behavior (television, video games, computer use) was assessed via questionnaire, and LTL was extracted from DNA in whole blood with the LTL assay performed using quantitative polymerase chain reaction. After adjustments (including age and physical activity), for every 1-hour increase in leisure-time screen-based sedentary behavior, participants had a 7% increased odds (odds ratio, 1.07; 95% CI, 1.00-1.13; P=.04) of having LTL in the lowest tertile (vs highest); leisure-time screen-based sedentary behavior was not associated with values in themiddle (vs highest) tertile (odds ratio, 1.01; 95% CI, 0.95-1.07; P=.62). The results of this study revealed that greater leisure-time screen-based sedentary behavior is associated with shorter LTL. (C) 2015 Mayo Foundation for Medical Education and Research
机译：久坐行为流行病学领域正在兴起。短的白细胞端粒长度（LTL）是衰老的标志性特征，但LTL也与发病率和死亡率无关，与年龄无关。据我所知，只有一项研究检查了久坐行为和LTL之间的关系。这项研究的目的是检查基于屏幕的久坐行为和LTL之间的关联。使用了1999-2002年全国健康和营养检查调查的数据（N = 6405;年龄20-84岁）。通过问卷调查评估基于休闲时间屏幕的久坐行为（电视，视频游戏，计算机使用情况），并使用定量聚合酶链反应进行LTL分析，从全血DNA中提取LTL。进行调整（包括年龄和体育锻炼）后，基于休闲时间的屏幕久坐行为每增加1小时，参与者的几率就会增加7％（赔率，1.07; 95％CI，1.00-1.13; P =。 04）LTL处于最低三分位数（vs最高）;基于闲暇时间屏幕的久坐行为与中间（相对于最高）三分位数中的值无关（优势比为1.01; 95％CI为0.95-1.07; P = .62）。这项研究的结果表明，休闲时基于屏幕的久坐行为越多，LTL越短。 （C）2015年梅奥医学教育与研究基金会

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