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Psychopathology and the binding problem.

机译:心理病理学和约束问题。

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摘要

Normal cerebral activity is based on the rapid and flexible alternation of an enormous quantity of spatial-temporal patterns of neuronal firing. There is still much to learn about the mechanism that keeps neurons on functionally closed assemblies firing in synchronization. The explanation of this mechanism is the so called 'binding problem', one of the cornerstones of the generation of perceptions, cognitions, emotions and behaviours by the brain, and therefore of great interest to psychiatry. We explore the possibility that a 'binding dysfunction' could be a relevant aspect of the pathophysiology of mental disorders, and apply it to schizophrenia, in an attempt to integrate some neurobiological findings in this disorder, including a few preliminary data obtained with transcranial magnetic stimulation (TMS).
机译:正常的大脑活动基于大量神经元放电的时空模式的快速灵活变化。关于使保持功能闭合的程序集上的神经元同步触发的机制的知识还有很多。这种机制的解释是所谓的“束缚问题”,是大脑产生感知,认知,情感和行为的基石之一,因此对精神病学非常感兴趣。我们探索“结合功能障碍”可能是精神障碍病理生理学的一个相关方面的可能性,并将其应用于精神分裂症,以试图整合该疾病的一些神经生物学发现,包括经颅磁刺激获得的一些初步数据(TMS)。

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