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首页> 外文期刊>Medical hypotheses >Confirmation of the 'protein-traffic-hypothesis' and the 'protein-localization-hypothesis' using the diabetes-mellitus-type-1-knock-in and transgenic-murine-models and the trepitope sequences
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Confirmation of the 'protein-traffic-hypothesis' and the 'protein-localization-hypothesis' using the diabetes-mellitus-type-1-knock-in and transgenic-murine-models and the trepitope sequences

机译：使用糖尿病-类型1-敲入和转基因-鼠模型和三肽表位序列确认“蛋白质交通假说”和“蛋白质定位假说”

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摘要

As possible mechanisms to explain the emergence of autoimmune diseases, the current author has suggested in earlier papers two new pathways: the "protein localization hypothesis" and the "protein traffic hypothesis". The "protein localization hypothesis" states that an autoimmune disease develops if a protein accumulates in a previously unoccupied compartment, that did not previously contain that protein. Similarly, the "protein traffic hypothesis" states that a sudden error within the transport of a certain protein leads to the emergence of an autoimmune disease. The current article discusses the usefulness of the different commercially available transgenic murine models of diabetes mellitus type 1 to confirm the aforementioned hypotheses. This discussion shows that several transgenic murine models of diabetes mellitus type 1 are in-line and confirm the aforementioned hypotheses. Furthermore, these hypotheses are additionally inline with the occurrence of several newly discovered protein sequences, the so-called trepitope sequences. These sequences modulate the immune response to certain proteins. The current study analyzed to what extent the hypotheses are supported by the occurrence of these new sequences. Thereby the occurrence of the trepitope sequences provides additional evidence supporting the aforementioned hypotheses. Both the "protein localization hypothesis" and the "protein traffic hypothesis" have the potential to lead to new causal therapy concepts. The "protein localization hypothesis" and the "protein traffic hypothesis" provide conceptional explanations for the diabetes mouse models as well as for the newly discovered trepitope sequences.
机译：作为解释自身免疫性疾病出现的可能机制，当前作者在较早的论文中提出了两种新途径：“蛋白质定位假说”和“蛋白质运输假说”。 “蛋白质定位假说”指出，如果一种蛋白质堆积在一个以前没有人居住的空位中，则这种疾病会发展为自身免疫疾病。类似地，“蛋白质运输假说”指出某种蛋白质运输中的突然错误导致自身免疫疾病的出现。当前的文章讨论了不同的1型糖尿病商业上可买到的转基因鼠模型对确认上述假设的有用性。讨论表明，几种1型糖尿病转基因鼠模型是在线的，并证实了上述假设。此外，这些假设还与几个新发现的蛋白质序列（所谓的三肽序列）的出现有关。这些序列调节对某些蛋白质的免疫应答。当前的研究分析了这些新序列的出现在多大程度上支持了这些假设。因此，三联序列的出现提供了支持上述假设的其他证据。 “蛋白质定位假说”和“蛋白质运输假说”都有可能导致新的因果疗法概念。 “蛋白质定位假说”和“蛋白质运输假说”为糖尿病小鼠模型以及新发现的三萜序列提供了概念上的解释。

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