• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medical hypotheses >Genomic evidence for antibiotic resistance genes of actinomycetes as origins of antibiotic resistance genes in pathogenic bacteria simply because actinomycetes are more ancestral than pathogenic bacteria.
【24h】

Genomic evidence for antibiotic resistance genes of actinomycetes as origins of antibiotic resistance genes in pathogenic bacteria simply because actinomycetes are more ancestral than pathogenic bacteria.

机译：放线菌的抗生素抗性基因是致病菌中抗生素抗性基因的起源的基因组证据，仅仅是因为放线菌比致病菌更祖传。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although in silico analysis have suggested that the antibiotic resistance genes in actinomycetes appear to be the origins of some antibiotic resistance genes, we have shown that recent horizontal transfer of antibiotic resistance genes from actinomycetes to other medically important bacteria have not taken place. Although it has been speculated in Benveniste and Davies' attractive hypothesis that antibiotic resistance genes of actinomycetes are origins of antibiotic resistance genes in pathogenic bacteria because the actinomycetes require mechanisms such as metabolic enzymes (encoded by the antibiotic resistance genes) to degrade the antibiotics they produce or to transport the antibiotics outside the bacterial cells, this hypothesis has never been proven. Both the phylogenetic tree constructed using 16S rRNA gene sequences and that constructed using concatenated amino acid sequences of 15 housekeeping genes extracted from 90 bacterial genomes showed that the actinomycetes is more ancestral to most other bacteria, including the pathogenic Gram-negative bacteria, Gram-positive bacteria, and Chlamydia species. Furthermore, the tetracycline resistance gene of Bifidobacterium longum is more ancestral to those of other pathogenic bacteria and the actinomycetes, which is in line with the ancestral position of B. longum. These suggest that the evolution of antibiotic resistance genes of antibiotic-producing bacteria in general parallels the evolution of the corresponding bacteria. The ancestral position of the antibiotic resistance genes in actinomycetes is probably unrelated to the fact that they produce antibiotics, but simply because actinomycetes are more ancestral than pathogenic bacteria.
机译：尽管计算机分析表明放线菌中的抗生素抗性基因似乎是某些抗生素抗性基因的起源，但我们已经表明，最近尚未发生抗生素抗性基因从放线菌向其他医学上重要细菌的水平转移。尽管在Benveniste和Davies的迷人假说中已经推测，放线菌的抗生素抗性基因是致病菌中抗生素抗性基因的起源，因为放线菌需要诸如代谢酶（由抗生素抗性基因编码）等机制来降解它们产生的抗生素。还是将抗生素运送到细菌细胞外，这一假设从未得到证实。使用16S rRNA基因序列构建的系统树和使用从90个细菌基因组中提取的15个管家基因的连接氨基酸序列构建的系统树都表明，放线菌比大多数其他细菌（包括致病性革兰氏阴性细菌，革兰氏阳性细菌）更为祖先。细菌和衣原体物种。此外，长双歧杆菌的四环素抗性基因比其他病原细菌和放线菌的祖先​​更祖先，这与长双歧杆菌的祖先位置一致。这些表明产生抗生素的细菌的抗生素抗性基因的进化通常与相应细菌的进化平行。放线菌中抗生素抗性基因的祖先位置可能与它们产生抗生素的事实无关，但这仅仅是因为放线菌比病原菌更祖传。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号