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A nonlinear identification method to study effective connectivity in functional MRI.

机译:研究功能性MRI中有效连通性的非线性识别方法。

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摘要

In this paper we propose a novel approach for characterizing effective connectivity in functional magnetic resonance imaging (fMRI) data. Unlike most other methods, our approach is nonlinear and does not rely on a priori specification of a model that contains structural information of neuronal populations. Instead, it relies on a nonlinear autoregressive exogenous model and nonlinear system identification theory; the model's nonlinear connectivities are determined using a least squares method. A statistical test was developed to quantify the significance of the influence that regions exert on one another. We compared this approach with a linear method and applied it to the human visual cortex network. Results show that this method can be used to model nonlinear interaction between different regions for fMRI data.
机译:在本文中,我们提出了一种用于表征功能磁共振成像(fMRI)数据中有效连接性的新颖方法。与大多数其他方法不同,我们的方法是非线性的,并且不依赖于包含神经元种群结构信息的模型的先验规范。相反,它依赖于非线性自回归外生模型和非线性系统识别理论。使用最小二乘法确定模型的非线性连通性。开发了一种统计测试,以量化区域相互影响的重要性。我们将该方法与线性方法进行了比较,并将其应用于人类视觉皮层网络。结果表明,该方法可用于为fMRI数据建模不同区域之间的非线性相互作用。

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