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首页> 外文期刊>Medical image analysis >Evaluation of using absolute versus relative base level when analyzing brain activation images using the scale-space primal sketch.
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Evaluation of using absolute versus relative base level when analyzing brain activation images using the scale-space primal sketch.

机译:使用比例空间原始草图分析大脑激活图像时,评估使用绝对基准水平还是相对基准水平。

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摘要

A dominant approach to brain mapping is to define functional regions in the brain by analyzing images of brain activation obtained from positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). This paper presents an evaluation of using one such tool, called the scale-space primal sketch, for brain activation analysis. A comparison is made concerning two possible definitions of a significance measure of blob structures in scale-space, where local contrast is measured either relative to a local or global reference level. Experiments on real brain data show that (i) the global approach with absolute base level has a higher degree of correspondence to a traditional statistical method than a local approach with relative base level, and that (ii) the global approach with absolute base level gives a higher significance to small blobs that are superimposed on larger scale structures, whereas the significance of isolated blobs largely remains unaffected. Relative to previously reported works, the following two technical improvements are also presented. (i) A post-processing tool is introduced for merging blobs that are multiple responses to image structures. This simplifies automated analysis from the scale-space primal sketch. (ii) A new approach is introduced for scale-space normalization of the significance measure, by collecting reference statistics of residual noise images obtained from the general linear model.
机译:大脑映射的一种主要方法是通过分析从正电子发射断层扫描(PET)和功能磁共振成像(fMRI)获得的大脑激活图像来定义大脑中的功能区域。本文介绍了使用一种称为比例空间原始草图的工具进行大脑激活分析的评估。比较了标度空间中斑点结构的有效度度量的两个可能定义,其中相对于局部或全局参考水平测量局部对比度。对真实大脑数据的实验表明,(i)具有绝对基础水平的全局方法与具有相对基础水平的局部方法的对传统统计方法的对应程度更高,并且(ii)具有绝对基础水平的全局方法可以提供对于叠加在较大规模结构上的小斑点,其重要性更高,而孤立斑点的重要性在很大程度上不受影响。相对于先前报道的作品,还提出了以下两项技术改进。 (i)引入了一种后处理工具,用于合并对图像结构有多种响应的斑点。这简化了从比例空间原始草图进行的自动分析。 (ii)通过收集从一般线性模型获得的残留噪声图像的参考统计信息,引入了一种新的方法来对有效度量进行尺度空间归一化。

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