Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients.

Takao Y; Yamada A; Yutani S; Ono T; Nagao Y; Ando E; Ide T; Itoh K; Sata M

首页> 外文期刊>Medical Microbiology and Immunology >Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients.

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Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients.

机译：在感染HCV的患者中，位于35-44位的HCV1b核心肽的血清IgG水平与持续感染相关，而位于2132-2140位的NS5A肽的血清IgG水平与更好的预后相关。

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We previously reported that two IgG Abs to the hepatitis C virus (HCV), anti-core 35-44 (C35) and anti-NS5A 2132-2140 (NS5A2132), existed in the sera of the majority of patients with HCV infection. This study investigated if measuring the two Abs would facilitate the prediction of a patient's prognosis. The serum levels of anti-C35 were found to correlate with persistent infection, while those of anti-NS5A2132 correlated with a better prognosis in HCV-infected patients. These results suggest that sequential measurement of the two Abs together may provide new information for the prediction of prognosis.

机译：我们先前曾报道大多数丙型肝炎病毒感染患者的血清中存在两种针对丙型肝炎病毒（HCV）的IgG抗体，即抗核心35-44（C35）和抗NS5A 2132-2140（NS5A2132）。这项研究调查了测量两种抗体是否有助于预测患者的预后。发现抗C35的血清水平与持续感染相关，而抗NS5A2132的血清水平与HCV感染患者的预后更好相关。这些结果表明，两个Abs的顺序测量可以为预测预后提供新的信息。

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来源
《Medical Microbiology and Immunology》 |2007年第3期|共8页
作者
Takao Y; Yamada A; Yutani S; Ono T; Nagao Y; Ando E; Ide T; Itoh K; Sata M;
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正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;医学免疫学;
关键词
Hepatitis C virus; prognostic; Immunoglobulin G measurement; Infection as complication of medical care; 肽类;

机译：丙型肝炎病毒;预后;免疫球蛋白G的测定;感染作为医疗并发症;肽类;

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1. Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients. [J] . Takao Y, Yamada A, Yutani S, Medical Microbiology and Immunology . 2007,第3期

机译：在感染HCV的患者中，位于35-44位的HCV1b核心肽的血清IgG水平与持续感染相关，而位于2132-2140位的NS5A肽的血清IgG水平与更好的预后相关。
2. Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels [J] . Marloes Vissers, Inge M. L. Ahout, Marien I. de Jonge, Clinical and vaccine immunology: CVI . 2016,第3期

机译：黏膜IgG水平与呼吸道合胞病毒负荷和炎症的相关性高于血浆IgG水平
3. Brief Report Number of Circulating Follicular Helper 2 T Cells Correlates With IgG4 and Interleukin-4 Levels and Plasmablast Numbers in IgG4-Related Disease [J] . Akiyama Mitsuhiro, Suzuki Katsuya, Yamaoka Kunihiro, Arthritis & rheumatology. . 2015,第9期

机译：简要报告循环卵泡辅助2 T细胞的数目与IgG4相关疾病中的IgG4和白细胞介素4水平和成浆细胞数目相关
4. Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels [O] . Marloes Vissers, Inge M. L. Ahout, Marien I. de Jonge, 2016

机译：黏膜IgG水平与呼吸道合胞病毒负荷和炎症的相关性高于血浆IgG水平
5. Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels [O] . Vissers, M.E.P., Ahout, I.M., Jonge, M.I. de, 2016

机译：黏膜IgG水平与呼吸道合胞病毒负荷和炎症的相关性高于血浆IgG水平

Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients.

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