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首页> 外文期刊>Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research >Prostate cancer, serum parathyroid hormone, and the progression of skeletal metastases.
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Prostate cancer, serum parathyroid hormone, and the progression of skeletal metastases.

机译：前列腺癌，血清甲状旁腺激素和骨骼转移的进展。

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摘要

Bony metastases from prostate cancer are a significant cause of morbidity and mortality. These metastases are predominantly blastic (bone-forming) and commonly cause increased serum levels of parathyroid hormone (PTH) as calcium ions are transferred from serum into blastic bone. The epidemiologic and clinical significance of secondary hyperparathyroidism in advanced prostate cancer have not been widely appreciated. Prostate cancer bony metastases show increased expression of the PTH receptor (PTH-IR) and PTH promotes the growth and invasiveness of prostate cancer cells in bone. Thus, blastic metastases appear to induce a "vicious cycle" in which PTH resorbs normal bone to support the growth of blastic bone. Recognition of the potential role of PTH in the progression of skeletal metastases suggests novel opportunities for prostate cancer secondary prevention. In particular, we propose that suppressing serum PTH in advanced prostate cancer may reduce morbidity by decreasing fractures and pain caused by bone resorption and may reduce mortality by retarding the progression of metastatic disease.
机译：前列腺癌的骨转移是发病和死亡的重要原因。这些转移主要是成骨的（成骨的），通常是由于钙离子从血清转移到成骨中而导致血清甲状旁腺激素（PTH）水平升高。晚期前列腺癌继发性甲状旁腺功能亢进症的流行病学和临床意义尚未得到广泛认可。前列腺癌骨转移显示PTH受体（PTH-IR）的表达增加，PTH促进骨中前列腺癌细胞的生长和侵袭性。因此，原发性转移似乎引起“恶性循环”，其中PTH吸收正常骨以支持原发性骨的生长。对PTH在骨骼转移过程中潜在作用的认识表明，前列腺癌二级预防的新机会。特别地，我们提出抑制晚期前列腺癌中的血清PTH可以通过减少由骨吸收引起的骨折和疼痛来降低发病率，并可以通过延迟转移性疾病的进展来降低死亡率。

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