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首页> 外文期刊>Medical Microbiology and Immunology >Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens.
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Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens.

机译：蠕虫感染使小鼠易患肺炎球菌性肺炎，但不易患其他肺炎性病原体。

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Pneumonia is the leading killer of children worldwide. Here, we report that helminth-infected mice develop fatal pneumonia when challenged with Streptococcus pneumoniae. Mice were chronically infected with either the flatworm Taenia crassiceps or the roundworm Heligmosomoides polygyrus. Upon challenge with a pneumonic type 3 strain of S. pneumoniae (A66.1), the worm-infected mice developed pneumonia at a rate and to a degree higher than age-matched control mice as measured by bioluminescent imaging and lung titers. This predisposition to pneumonia appears to be specific to S. pneumoniae, as worm-infected mice did not show evidence of increased morbidity when challenged with a lethal dose of influenza virus or sublethal doses of Staphylococcus aureus or Listeria monocytogenes. The defect was also present when worm-infected mice were challenged with a type 2 sepsis-causing strain?(D39); an increased rate of pneumonia, decreased survival, and increased lung and blood titers were found. Pneumococcal colonization and immunity against acute otitis media were unaffected. Anti-helminthic treatment in the H. polygyrus model reversed this susceptibility. We conclude that helminth coinfection predisposes mice to fatal pneumococcal pneumonia by promoting increased outgrowth of bacteria in the lungs and blood. These data have broad implications for the prevention and treatment for pneumonia in the developing world, where helminth infections are endemic and pneumococcal pneumonia is common.
机译：肺炎是全球儿童的主要杀手。在这里，我们报道蠕虫感染的小鼠在受到肺炎链球菌攻击时会发生致命性肺炎。小鼠被扁虫flat虫Taenia crassiceps或the虫Heligmosomoides polygyrus慢性感染。用肺炎链球菌肺炎3型毒株（A66.1）攻击后，蠕虫感染的小鼠发生肺炎的速度和程度要高于通过生物发光成像和肺滴度测定的年龄匹配的对照小鼠。这种肺炎的易感性似乎是肺炎链球菌的特异性，因为当用致死剂量的流感病毒或亚致死剂量的金黄色葡萄球菌或单核细胞增生李斯特菌攻击时，蠕虫感染的小鼠没有显示出发病率增加的证据。当蠕虫感染的小鼠用引起2型败血症的菌株（D39）攻击时也存在该缺陷。发现增加了肺炎的发生率，降低了生存率，并增加了肺和血液滴度。肺炎球菌定植和针对急性中耳炎的免疫力均未受影响。在多头H.模型中的抗蠕虫治疗逆转了这种敏感性。我们得出的结论是，蠕虫共感染通过促进肺和血液中细菌的增生而使小鼠易患致命的肺炎球菌性肺炎。这些数据对发展中国家的肺炎的预防和治疗具有广泛的意义，因为那里的蠕虫感染是地方病，肺炎球菌性肺炎很普遍。

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