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首页> 外文期刊>Medical and Pediatric Oncology: The Official Journal of the American Association for Cancer Education >Long-term outcome of patients with intraspinal neuroblastoma.
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Long-term outcome of patients with intraspinal neuroblastoma.

机译：脊髓内神经母细胞瘤患者的长期预后。

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BACKGROUND: Chemotherapy, radiotherapy, and surgical decompression with laminectomy are effective therapeutic options in the treatment of cord compression from neuroblastoma (NB). We report the long-term outcome of patients with intraspinal NB treated with or without laminectomy at two large pediatric oncology centers. PROCEDURE: We reviewed the medical records and radiographs of 26 children with intraspinal NB treated at Children's Memorial Hospital in Chicago, Illinois, between 1985 and 1994 or at St. Jude Children's Research Hospital in Memphis, Tennessee, between 1967 and 1992. RESULTS: Twenty-four of the 26 patients are alive and disease-free (follow-up of 2-29 years; median, 10 years 2 months). Fifteen of the 23 patients with neurologic impairment underwent initial laminectomy. Nine of these 15 patients recovered neurologic function, including 3 patients who presented with paraplegia. Eleven of the 15 patients who underwent laminectomy have developed mild to severe spinal deformities. Eight patients with neurologic symptoms consequent to cord compression were treated with initial chemotherapy and/or surgery, but did not undergo laminectomy. Three patients with mild to moderate deficits recovered neurologic function. Four of 11 patients with intraspinal NB who did not undergo laminectomy have mild to severe scoliosis. CONCLUSIONS: A low incidence of neurologic recovery was seen in patients with long-standing severe cord compression regardless of treatment modality. For patients with partial neurologic deficits, recovery was seen in most patients following chemotherapy or surgical decompression with laminectomy. A higher incidence of spinal deformities was seen in the patients treated with initial laminectomy.
机译：背景：椎板切除术的化学疗法，放射疗法和外科减压是治疗神经母细胞瘤（NB）的脐带压迫的有效治疗选择。我们报告了在两个大型儿科肿瘤中心接受或不接受椎板切除术治疗的椎管内NB患者的长期结局。程序：我们回顾了1985年至1994年在伊利诺伊州芝加哥儿童纪念医院或田纳西州孟菲斯的圣裘德儿童研究医院接受治疗的26例椎管内NB儿童的病历和X线照片。结果：20岁-26例患者中有4例仍然活着并且没有疾病（随访时间为2-29年;中位数为10年2个月）。 23例神经功能缺损患者中有15例接受了初次椎板切除术。这15名患者中有9名恢复了神经功能，包括3名出现截瘫的患者。在接受椎板切除术的15名患者中，有11名出现了轻度至严重的脊柱畸形。八名因脊髓受压而导致神经系统症状的患者接受了初始化疗和/或手术治疗，但未进行椎板切除术。三例轻度至中度缺陷的患者恢复了神经功能。未进行椎板切除术的11例椎管内NB患者中有4例出现轻度至重度脊柱侧弯。结论：长期接受重度脊髓压迫的患者，无论采用何种治疗方式，其神经系统恢复的发生率均较低。对于部分神经功能缺损的患者，大多数患者在进行化学疗法或椎板切除术减压后可看到恢复。初次椎板切除术治疗的患者中脊柱畸形的发生率更高。

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