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首页> 外文期刊>Medical and Pediatric Oncology: The Official Journal of the American Association for Cancer Education >Primary gastric Burkitt lymphoma in childhood: associated with Helicobacter pylori?
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Primary gastric Burkitt lymphoma in childhood: associated with Helicobacter pylori?

机译：儿童原发性伯基特胃部淋巴瘤：与幽门螺杆菌相关？

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BACKGROUND: This retrospective study was designed to estimate the incidence of primary gastric non-Hodgkin lymphoma (NHL) in childhood and the possible association with Helicobacter pylori (H. pylori). PROCEDURE: We reviewed and analyzed the charts of 135 patients with NHL that were diagnosed and treated in a single oncology unit during the last 20 years. RESULTS: Only two patients, 5 and 12 years old, with primary gastric NHL were found. Upper gastroduodenal endoscopy detected an ulcer in the lesser curvature of the body of the stomach, in both cases. Endoscopy revealed a moderate chronic gastritis in the antrum of both patients that was H. pylori associated in one of them who also suffered from chronic gastritis. Biopsy specimens demonstrated infiltration by Burkitt lymphoma (BL). The two patients received chemotherapy for 6 months. Additionally, one of the two patients received a triple therapy regimen with bismuth, amoxicillin, and metronidazole for H. pylori. Fifteen and six years later they are in complete remission, free of symptoms. CONCLUSIONS: Primary gastric NHL in childhood is rare. It was found in fewer than 2% of our NHL patients. The temporal relationship between the H. pylori infection and BL suggest a causative link between these two events.
机译：背景：这项回顾性研究旨在评估儿童期原发性胃非霍奇金淋巴瘤（NHL）的发生率以及与幽门螺杆菌（H. pylori）的可能关系。程序：我们回顾并分析了过去20年中在单一肿瘤科中诊断和治疗的135名NHL患者的图表。结果：仅发现两名分别为5岁和12岁的原发性胃NHL患者。在两种情况下，上十二指肠胃镜均在胃小弯处发现溃疡。内窥镜检查显示两名患者的胃窦均出现中度慢性胃炎，其中一名患者患有幽门螺杆菌，也患有慢性胃炎。活检标本显示Burkitt淋巴瘤（BL）浸润。两名患者接受了6个月的化疗。此外，两名患者中的一名接受了针对幽门螺杆菌的铋，阿莫西林和甲硝唑的三联疗法。十五和六年后，他们完全缓解，没有症状。结论：儿童期原发性胃NHL罕见。在我们不到2％的NHL患者中发现了它。幽门螺杆菌感染与BL之间的时间关系表明这两个事件之间存在因果关系。

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