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首页> 外文期刊>Medical and Pediatric Oncology: The Official Journal of the American Association for Cancer Education >Degree of fatness after treatment of malignant lymphoma in childhood.
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Degree of fatness after treatment of malignant lymphoma in childhood.

机译：儿童恶性淋巴瘤治疗后的肥胖程度。

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BACKGROUND: Sex hormone deficiency or growth hormone deficiency may cause excess fatness after treatment for childhood malignant lymphoma. Previous studies of the body composition after treatment for childhood cancer included few survivors of malignant lymphoma who were not analysed separately. PROCEDURE: We measured the whole-body percent fat by dual energy X-ray absorptiometry (DXA) and the body-mass index (weight/height(2) (kg/m(2)), BMI) in survivors of childhood Hodgkin disease (n = 23) or non-Hodgkin lymphoma (n = 21) a median of 11 years after diagnosis (range 2-25). Results were compared with local data on 463 healthy controls. RESULTS: Adjusted for sex and age, the mean BMI did not differ from that of local controls, but the mean whole-body percent fat was significantly increased (0.8 SD above predicted, P = 0.0001). Sixteen of 44 participants had a percent fat above the 90 percentile of the reference values, which indicates excess fatness. Adjusted for sex and age, percent fat was significantly higher in persons treated for non-Hodgkin lymphoma. Controlled for this, the whole-body percent fat was not significantly related to sex, age at diagnosis, length of follow-up, sex hormone therapy at follow-up or the cumulative dose of corticosteroids or doxorubicin. CONCLUSIONS: Eleven years after diagnosis of childhood Hodgkin disease or non-Hodgkin lymphoma, the whole-body percent fat was increased whereas the BMI was like that of the controls. This indicates a reduced lean body mass.
机译：背景：性激素缺乏症或生长激素缺乏症可能在治疗儿童恶性淋巴瘤后引起过多的肥胖。先前对儿童期癌症治疗后身体成分的研究包括少数恶性淋巴瘤幸存者，没有单独分析。程序：我们通过双能X线吸收法（DXA）和体重指数（体重/身高（2）（kg / m（2）），BMI）测量了儿童霍奇金病幸存者的全身脂肪百分比（n = 23）或非霍奇金淋巴瘤（n = 21）在诊断后中位数为11年（范围2-25）。将结果与463名健康对照者的本地数据进行比较。结果：经性别和年龄调整后，平均B​​MI与本地对照无差异，但平均全身脂肪百分比显着增加（比预期高0.8 SD，P = 0.0001）。 44名参与者中有16名的脂肪百分比高于参考值的90％，这表明脂肪过多。经性别和年龄调整后，接受非霍奇金淋巴瘤治疗的人的脂肪百分比明显更高。因此，全身脂肪百分比与性别，诊断时的年龄，随访时间，随访时的性激素治疗或皮质类固醇或阿霉素的累积剂量没有显着相关。结论：诊断为儿童霍奇金病或非霍奇金淋巴瘤十一年后，全身脂肪百分比增加，而BMI与对照组相似。这表明瘦体重减少。

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