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首页> 外文期刊>Medicine and science in sports and exercise >No association between ACE gene variation and endurance athlete status in Ethiopians.
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No association between ACE gene variation and endurance athlete status in Ethiopians.

机译：在埃塞俄比亚人中，ACE基因变异与耐力运动员状态之间没有关联。

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PURPOSE: The most widely studied candidate gene for endurance performance is the angiotensin-converting enzyme (ACE) gene. The best endurance runners in the world hail from Kenya and Ethiopia, so the lack of association between the ACE gene and elite endurance athlete status we previously reported in Kenyans requires replication in Ethiopians. METHODS: DNA was extracted from buccal swabs collected from subjects filling four groups: elite endurance runners from the Ethiopian national athletics team specializing in 5 km to marathon distances (n = 76), controls demographically matched to the elite endurance athletes (n = 410), controls representing the general Ethiopian population (n = 317), and sprint and power event athletes from the Ethiopian national athletics team (n = 38). ACE I/D and A22982G (rs4363) genotype frequencies were determined for each of these groups, and differences between groups were assessed using chi(2) tests. RESULTS: There were no significant deviations from Hardy-Weinberg equilibrium in endurance athletes or either control group. Endurance athletes did not differ significantly in ACE I/D genotype frequency when compared with the endurance athlete-matched control group (P = 0.16), general controls (P = 0.076), or sprint and power athletes (P = 0.39) (endurance athletes: 15.8% II, endurance athlete-matched controls: 8.8% II, general controls: 7.6% II, sprint and power athletes: 10.5% II). Similarly, no significant differences were found in ACE A22982G genotype between groups (endurance athletes: 13.2% AA, endurance athlete-matched controls: 12.2% AA, general controls: 12.0% AA, sprint and power athletes: 13.2%; endurance athletes vs endurance athlete-matched controls: P = 0.97, endurance athletes vs general controls: P = 0.95, endurance athletes vs sprint and power athletes: P = 0.52). CONCLUSIONS: As previously shown in elite Kenyan athletes, ACE I/D and A22982G polymorphisms are not associated with elite endurance athlete status in Ethiopians.
机译：目的：耐力性能研究最广泛的候选基因是血管紧张素转化酶（ACE）基因。世界上最好的耐力跑者来自肯尼亚和埃塞俄比亚，因此我们先前在肯尼亚人中报道的ACE基因与精英耐力运动员身份之间缺乏关联，需要在埃塞俄比亚人中复制。方法：从四组受试者的颊拭子中提取DNA：埃塞俄比亚国家运动队的精英耐力跑者专门研究5公里到马拉松距离（n = 76），在人口统计学上与精英耐力运动员相匹配（n = 410） ，代表一般埃塞俄比亚人口的控件（n = 317），以及来自埃塞俄比亚国家田径队的冲刺和力量项目运动员（n = 38）。确定每个组的ACE I / D和A22982G（rs4363）基因型频率，并使用chi（2）测试评估组之间的差异。结果：耐力运动员或任一对照组的Hardy-Weinberg平衡均无显着偏差。与耐力运动员匹配的对照组（P = 0.16），一般对照组（P = 0.076）或短跑和强力运动员（P = 0.39）（耐力运动员）相比，耐力运动员的ACE I / D基因型频率无显着差异：15.8％II，耐力运动员匹配的控件：8.8％II，一般控件：7.6％II，短跑和力量运动员：10.5％II）。同样，各组之间ACE A22982G基因型之间也没有发现显着差异（耐力运动员：13.2％AA，耐力运动员匹配的对照组：12.2％AA，常规对照：12.0％AA，短跑和力量运动员：13.2％;耐力运动员vs耐力运动员配对控件：P = 0.97，耐力运动员vs普通控件：P = 0.95，耐力运动员vs短跑和力量运动员：P = 0.52）。结论：如先前在肯尼亚精英运动员中所示，ACE I / D和A22982G多态性与埃塞俄比亚人的精英耐力运动员状态无关。

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