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首页> 外文期刊>Medicine and science in sports and exercise >Comparative response of EPO and soluble transferrin receptor at high altitude.
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Comparative response of EPO and soluble transferrin receptor at high altitude.

机译：EPO和可溶性转铁蛋白受体在高海拔地区的比较响应。

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PURPOSE: Soluble transferrin receptor (sTfR) classically raises with increased erythropoiesis, along with the rise in erythropoietin (EPO). However, the specific effect of altitude-induced erythropoiesis on sTfR remains poorly documented. This study investigated the response of sTfR during high-altitude exposure in human and verified that sTfR was related to EPO response in this case. METHODS: EPO, sTfR, red cell volume (RCV), ferritin, and iron intake were measured during: 1) experiment A (N = 8, 31 d at 5000-8848 m), at sea level (SL), and at the simulated altitude of 5000, 6000, 7000, and 8000 m; and 2) during experiment B (N = 10, 7 d at 4350 m), at SL, after 3, 5, and 7 d at 4350 m and 1-2 d after return to SL (RSL). RESULTS: In experiment A, progressive decompression from SL to 8000 m induced a large parallel rise in EPO (33.8-fold) and sTfR (5.9-fold), whereas ferritin was dramatically decreased and iron intake reduced. RCV was increased after 31 d of decompression. In experiment B, EPO peaked at day 3 at 4350 m, then declined later at altitude and returned to baseline values at RSL, whereas sTfR progressively rose at altitude (+86%) and remained elevated during RSL (+64%). Ferritin progressively declined at 4350 m, whereas iron intake was unchanged. RCV was not enhanced after exposure to 4350 m. CONCLUSION: In summary, sTfR mirrors EPO response for a given level of altitude hypoxia but differs from EPO response during transitory phases, such as early acclimatization or reoxygenation. Analysis of sTfR may therefore account for altitude-related erythropoiesis, at a time when EPO is blunted.
机译：用途：可溶性转铁蛋白受体（sTfR）通常随着促红细胞生成的增加以及促红细胞生成素（EPO）的升高而升高。但是，关于高度诱导的红细胞生成对sTfR的特定作用的文献仍然很少。这项研究调查了人类高海拔暴露期间sTfR的反应，并验证了在这种情况下sTfR与EPO反应有关。方法：在以下情况下测量EPO，sTfR，红细胞体积（RCV），铁蛋白和铁的摄入量：1）实验A（在5000-8848 m时N = 8、31 d），在海平面（SL）和5000、6000、7000和8000 m的模拟高度;和2）在实验B（4350 m，N = 10、7 d）期间，在SL处，在返回SL（RSL）后的4350 m和1-2 d的3、5和7 d之后。结果：在实验A中，从SL到8000 m的减压逐渐引起EPO（33.8倍）和sTfR（5.9倍）的大量平行上升，而铁蛋白显着下降，铁摄入减少。减压31 d后RCV升高。在实验B中，EPO在第3天的4350 m处达到峰值，然后在海拔高度下降，并在RSL处恢复到基线值，而sTfR在海拔高度处逐渐上升（+ 86％），在RSL期间仍保持升高（+ 64％）。铁蛋白在4350 m处逐渐下降，而铁的摄入量未变。暴露于4350 m后，RCV没有增强。结论：总而言之，sTfR反映了给定海拔高度缺氧时的EPO反应，但与过渡阶段（如早期适应或复氧）中的EPO反应不同。因此，在EPO变钝时，对sTfR的分析可能会解释与海拔相关的红细胞生成。

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