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首页> 外文期刊>Medicine and science in sports and exercise >Exercise, depression, and mortality after myocardial infarction in the ENRICHD trial.
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Exercise, depression, and mortality after myocardial infarction in the ENRICHD trial.

机译：在ENRICHD试验中，心肌梗塞后的运动，抑郁和死亡率。

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PURPOSE: The large and well-characterized population of acute myocardial infarction (AMI) patients studied in the recently completed Enhancing Recovery in Coronary Heart Disease (ENRICHD) multicenter clinical trial provides a unique opportunity to examine the importance of self-reported regular physical exercise in a large cohort of patients with a recent AMI who are depressed or report low levels of social support. METHODS: We prospectively examined the association between self-reported physical exercise and all-cause mortality and cardiovascular morbidity among 2078 men (N = 1175; 56.5%) and women (N = 903; 43.5%) with an AMI participating in the ENRICHD Trial. Six months after suffering an AMI, patients were surveyed about their exercise habits and were then followed for up to 4 yr. RESULTS: During an average 2 yr of follow-up, 187 fatal events occurred. Patients reporting regular exercise had less than half the events (5.7%) of those patients reporting they did not regularly exercise (12.0%). Afteradjustment for medical and demographic variables, the hazard ratio for fatal events was 0.62 (95% CI = 0.44-0.86, P = 0.004). The rate of nonfatal AMI among the exercisers was 6.5% compared with 10.5% who reported no regular exercise. After adjustment for covariates, the hazard ratio for nonfatal AMI was 0.72 (95% CI = 0.52-0.99, P = 0.044). CONCLUSIONS: The present findings demonstrate the potential value of exercise in reducing mortality and nonfatal reinfarction in AMI patients at increased risk for adverse events by virtue of their either being depressed or having low social support.
机译：目的：在最近完成的《增强冠心病康复》（ENRICHD）多中心临床试验中研究的大量急性心肌梗死（AMI）患者，为研究自我报告定期进行体育锻炼的重要性提供了独特的机会。一大批患有近期AMI的患者，他们患有抑郁症或社会支持水平较低。方法：我们前瞻性检查了参加AMI参加ENRICHD试验的2078名男性（N = 1175; 56.5％）和女性（N = 903; 43.5％）的自我报告的体育锻炼与全因死亡率和心血管疾病发病率之间的关系。 。患AMI后六个月，对患者的运动习惯进行了调查，然后随访长达4年。结果：在平均2年的随访期间，发生了187例致命事件。报告定期运动的患者发生事件的比例少于报告不定期运动的患者（5.7％）的一半（12.0％）。在对医学和人口统计学变量进行调整后，致命事件的危险比为0.62（95％CI = 0.44-0.86，P = 0.004）。锻炼者中非致命性AMI的发生率为6.5％，而没有定期锻炼者为10.5％。调整协变量后，非致死性AMI的危险比为0.72（95％CI = 0.52-0.99，P = 0.044）。结论：本研究结果表明，运动对降低因抑郁症或社会支持不足而导致不良事件风险增加的AMI患者的死亡率和非致死性再梗塞的潜在价值。

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