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首页> 外文期刊>Medical oncology >Expression and clinical significance of microRNA-326 in human glioma miR-326 expression in glioma.
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Expression and clinical significance of microRNA-326 in human glioma miR-326 expression in glioma.

机译：microRNA-326在人脑胶质瘤中的表达及其临床意义miR-326在脑胶质瘤中的表达。

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As a suppressor of Hedgehog signaling pathway, microRNA-326 (miR-326) has been demonstrated to control the development of cerebellar neuronal progenitor and tumor cells. More recently, it has been reported that miR-326 was down-regulated in glioblastoma tissues and might regulate the metabolic activity of glioma and glioma stem cells, suggesting the involvement of miR-326 in tumorigenesis and progression of gliomas. However, the role of miR-326 in human glioma has not been clearly understood. Therefore, the aim of this study was to investigate the clinical significance of miR-326 expression in human glioma. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-326 in 108 glioma and 20 normal brain tissues. The associations of miR-326 expression with clinicopathological factors and prognosis of glioma patients were also statistically analyzed. The expression levels of miR-326 in glioma tissues were significantly lower than those in normal brain tissues (P < 0.001). Additionally, the decreased miR-326 expression in glioma was significantly associated with advanced pathological grade (P = 0.01) and low Karnofsky performance score (KPS, P = 0.03). Moreover, Kaplan-Meier survival and Cox regression analyses showed that low expression of miR-326 (P = 0.01) and advanced pathological grade (P = 0.02) were independent factors predicting poor prognosis for gliomas. Furthermore, subgroup analyses showed that miR-326 expression was significantly associated with poor overall survival in glioma patients with high pathological grades (for grade III-IV: P < 0.001). Down-regulation of miR-326 may have potential value for predicting clinical outcomes in glioma patients with high pathological grades, suggesting that miR-326 is an important candidate tumor suppressor, and its down-regulated expression may contribute to glioma progression.
机译：作为Hedgehog信号通路的抑制剂，已证明microRNA-326（miR-326）可控制小脑神经元祖细胞和肿瘤细胞的发育。最近，据报道，在胶质母细胞瘤组织中miR-326被下调，并可能调节神经胶质瘤和神经胶质瘤干细胞的代谢活性，表明miR-326参与了神经胶质瘤的发生和发展。但是，尚未明确了解miR-326在人脑胶质瘤中的作用。因此，本研究的目的是研究人胶质瘤中miR-326表达的临床意义。实时定量聚合酶链反应（qRT-PCR）分析用于表征miR-326在108个神经胶质瘤和20个正常脑组织中的表达模式。还对miR-326表达与脑胶质瘤患者临床病理因素和预后的关系进行了统计学分析。胶质瘤组织中miR-326的表达水平明显低于正常脑组织（P <0.001）。此外，神经胶质瘤中miR-326表达的下降与病理分级高（P = 0.01）和低卡氏评分（KPS，P = 0.03）显着相关。此外，Kaplan-Meier生存率和Cox回归分析表明，miR-326的低表达（P = 0.01）和病理等级高（P = 0.02）是预测神经胶质瘤预后不良的独立因素。此外，亚组分析显示，在病理等级较高的神经胶质瘤患者中，miR-326的表达与总体生存不良相关（对于III-IV级：P <0.001）。 miR-326的下调可能具有预测具有较高病理学等级的神经胶质瘤患者临床预后的潜在价值，这表明miR-326是重要的候选肿瘤抑制因子，其下调的表达可能有助于神经胶质瘤的进展。

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