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首页> 外文期刊>Medical oncology >Anticancer effect of realgar nanoparticles on mouse melanoma skin cancer in vivo via transdermal drug delivery.
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Anticancer effect of realgar nanoparticles on mouse melanoma skin cancer in vivo via transdermal drug delivery.

机译：雄黄纳米粒通过透皮药物递送在体内对小鼠黑色素瘤皮肤癌的抗癌作用。

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摘要

Realgar has been used successfully to treat diseases for thousands of years, but its poor water solubility and high toxicity hampered its further medical uses. Here, we first applied transdermal drug delivery system to deliver realgar nanoparticles to investigate its anticancer effect and toxicity in vivo. In this study, MTT assay and flow cytometry analysis demonstrated that realgar significantly suppressed the proliferation and induced apoptosis of B16 melanoma cells in a dose-dependent manner. Transdermal penetration studies in vitro showed realgar nanoparticles could be delivered efficiently through skin. Tests on tumor-bearing C57BL/6 mice displayed that realgar could decrease the tumor volume markedly via transdermal drug delivery compared with the intraperitoneal administration and the control. Hematoxylin-eosin and immunohistochemical staining revealed that it could inhibit angiogenesis. The monitoring of the hepatic injury, body weight, feeding behavior, motor activity, and skin irritation of each animal indicated little toxicity of realgar to mice. The results demonstrated that realgar nanoparticles can be dermally delivered to achieve high efficacy against menaloma in vivo with low toxicity.
机译：雄黄已成功用于治疗疾病数千年，但其差的水溶性和高毒性阻碍了其进一步的医学用途。在这里，我们首先应用了透皮药物递送系统来递送雄黄纳米颗粒，以研究其抗癌作用和体内毒性。在这项研究中，MTT分析和流式细胞仪分析表明雄黄显着抑制B16黑色素瘤细胞的增殖并诱导其凋亡，并呈剂量依赖性。体外透皮渗透研究表明，雄黄纳米颗粒可以通过皮肤有效递送。对荷瘤C57BL / 6小鼠的测试表明，与腹膜内给药和对照组相比，雄黄可以通过透皮给药显着降低肿瘤体积。苏木精-曙红和免疫组化染色显示，它可以抑制血管生成。对每只动物的肝损伤，体重，进食行为，运动活动和皮肤刺激的监测表明，雄黄对小鼠的毒性很小。结果表明，雄黄纳米颗粒可以经皮递送，以体内低毒性实现对脑膜瘤的高效治疗。

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