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首页> 外文期刊>Medicine and science in sports and exercise >Acute Inactivity Impairs Glycemic Control but Not Blood Flow to Glucose Ingestion
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Acute Inactivity Impairs Glycemic Control but Not Blood Flow to Glucose Ingestion

机译：急性不活动会损害血糖控制，但不会影响血糖摄入

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Purpose: Insulin-stimulated increases in skeletal muscle blood flow play a role in glucose disposal. Indeed, 7 d of aerobic exercise in patients with Type 2 diabetes increased blood flow responses to an oral glucose tolerance test (OGTT) and improved insulin sensitivity. More recent work suggests that reduced daily physical activity impairs glycemic control (GC) in healthy individuals. Herein, we sought to determine whether an acute reduction in daily activity (from >10,000 to <5000 steps per day) for 5 d (RA5) in healthy individuals reduced insulin-stimulated blood flow and GC in parallel and if a 1-d return to activity (RTA1) improved these outcomes. Methods: OGTT were performed as a stimulus to increase insulin in 14 healthy, recreationally active men (24 +/- 1.1 yr) at baseline, RA5, and RTA1. Measures of insulin sensitivity (Matsuda index) and femoral and brachial artery blood flow were made during the OGTT. Free-living measures of GC including peak postprandial glucose (peak PPG) were also made via continuous glucose monitoring. Results: Femoral and brachial artery blood flow increased during the OGTT but neither was significantly impacted by changes in physical activity (P > 0.05). However, insulin sensitivity was decreased by RA5 (11.3 +/- 1.5 to 8.0 +/- 1.0, P < 0.05). Likewise, free-living GC measures of peak PPG (113 +/- 3 to 123 +/- 5 mg.dL(-1), P < 0.05) was significantly increased at RA5. Interestingly, insulin sensitivity and GC as assessed by peak PPG were not restored after RTA1 (P > 0.05). Conclusions: Thus, acute reductions in physical activity impaired GC and insulin sensitivity; however, blood flow responses to an OGTT were not affected. Further, a 1-d return to activity was not sufficient to normalize GC after 5 d of reduced daily physical activity.
机译：目的：胰岛素刺激的骨骼肌血流量的增加在葡萄糖的处置中起作用。实际上，患有2型糖尿病的患者7天的有氧运动增加了对口服葡萄糖耐量试验（OGTT）的血流反应并改善了胰岛素敏感性。最近的工作表明，减少日常体育锻炼会损害健康个体的血糖控制（GC）。本文中，我们试图确定健康个体5天（RA5）的每日活动（每天从10,000步降至<5000个步骤）的急性减少是否同时降低了胰岛素刺激的血流量和GC，以及是否返回了1-d活动（RTA1）改善了这些结果。方法：在基线，RA5和RTA1的基础上，对14名健康，有娱乐活动的男性（24 +/- 1.1岁）进行OGTT刺激，以增加其胰岛素。在OGTT期间测量胰岛素敏感性（Matsuda指数）以及股动脉和肱动脉的血流。还通过连续监测血糖来进行GC的自由活动措施，包括餐后血糖峰值（峰值PPG）。结果：在OGTT期间，股动脉和肱动脉血流量增加，但两者均不受体力活动变化的显着影响（P> 0.05）。但是，RA5降低了胰岛素敏感性（11.3 +/- 1.5至8.0 +/- 1.0，P <0.05）。同样，在RA5时，峰PPG的自由活动GC量度（113 +/- 3至123 +/- 5 mg.dL（-1），P <0.05）显着增加。有趣的是，RTA1后未恢复通过峰PPG评估的胰岛素敏感性和GC（P> 0.05）。结论：因此，体育活动的急剧减少损害了GC和胰岛素敏感性。但是，对OGTT的血流反应没有受到影响。此外，每天运动量减少5天后，恢复1天的活动量不足以使GC正常化。

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