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首页> 外文期刊>Medical oncology >Treatment on advanced NSCLC: Platinum-based chemotherapy plus erlotinib or platinum-based chemotherapy alone? A systematic review and meta-analysis of randomised controlled trials
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Treatment on advanced NSCLC: Platinum-based chemotherapy plus erlotinib or platinum-based chemotherapy alone? A systematic review and meta-analysis of randomised controlled trials

机译：晚期NSCLC的治疗：铂类化疗加厄洛替尼还是仅铂类化疗？随机对照试验的系统评价和荟萃分析

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摘要

We performed a systematic review and meta-analysis to assess the potential of erlotinib plus platinum-based chemotherapy relative to platinum-based chemotherapy alone for advanced non-small-cell lung cancer (NSCLC). Search of PubMed, EMBASE, Web of Science, CBM, CNKI, China Wan Fang databases and the Cochrane library was performed for studies regarding erlotinib plus platinum-based chemotherapy for advanced NSCLC published between 1 January 2000 and 28 August 2014. We identified eight eligible studies including 3,363 patients with advanced NSCLC. For PFS measure, an HR of 0.73 (0.58-0.93) with statistical significance was estimated when erlotinib plus platinum-based chemotherapy compared with platinum-based chemotherapy alone; objective response rate of 32.86 versus 24.85 % was obtained for both groups, respectively. HR of 0.93 (0.86-1.00) with P of 0.170 was calculated for OS. We concluded that the erlotinib plus chemotherapy for advanced NSCLC could increase PFS and objective response rate, but not benefit OS.
机译：我们进行了系统的综述和荟萃分析，以评估厄洛替尼加铂类化疗相对于单纯铂类化疗对于晚期非小细胞肺癌（NSCLC）的潜力。检索PubMed，EMBASE，Web of Science，CBM，CNKI，中国万方数据库和Cochrane库，以研究厄洛替尼加铂类晚期NSCLC化疗的相关研究。我们确定了8项合格药物研究包括3,363例晚期NSCLC患者。对于PFS测量，厄洛替尼联合铂类化疗与单纯铂类化疗相比，HR估计为0.73（0.58-0.93），具有统计学意义。两组的客观反应率分别为32.86％和24.85％。计算OS的HR为0.93（0.86-1.00），P为0.170。我们得出的结论是，厄洛替尼加化学疗法治疗晚期NSCLC可以提高PFS和客观缓解率，但不能改善OS。

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