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首页> 外文期刊>Medicine and science in sports and exercise >Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue.
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Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue.

机译：含硫抗氧化剂在延缓骨骼肌疲劳中的功效。

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Reactions involving thiol biochemistry seem to play a crucial role in skeletal muscle fatigue. N-acetylcysteine amide (NACA) and l-ergothioneine (ERGO) are thiol-based antioxidants available for human use that have not been evaluated for effects on muscle fatigue. PURPOSE: : To test the hypothesis that NACA and ERGO delay skeletal muscle fatigue. METHODS: : We exposed mouse diaphragm fiber bundles to buffer (CTRL), NACA, ERGO, or N-acetylcysteine (NAC; positive control). Treatments were performed in vitro using 10 mM for 60 min at 37 degrees C. After treatment, we determined the muscle force-frequency and fatigue characteristics. RESULTS: : The force-frequency relationship was shifted to the left by ERGO and to the right by NACA compared with CTRL and NAC. Maximal tetanic force was similar among groups. The total force-time integral (FTI; N.s.cm) during the fatigue trial was decreased by NACA (420 +/- 35, P < 0.05), unaffected by ERGO (657 +/- 53), and increased by NAC (P < 0.05) compared with CTRL (581 +/- 54). The rate of contraction (dF/dtMAX) during the fatigue trial was not affected by any of the treatments tested. NAC, but not NACA or ERGO, delayed the slowing of muscle relaxation (dF/dtMIN) during fatigue. CONCLUSIONS: : In summary, NACA and ERGO did not delay skeletal muscle fatigue in vitro. We conclude that these antioxidants are unlikely to improve human exercise performance.
机译：涉及硫醇生物化学的反应似乎在骨骼肌疲劳中起关键作用。 N-乙酰半胱氨酸酰胺（NACA）和1-麦角硫氨酸（ERGO）是可用于人类的基于硫醇的抗氧化剂，尚未评估其对肌肉疲劳的影响。目的：：测试NACA和ERGO延迟骨骼肌疲劳的假说。方法：：我们将小鼠隔膜纤维束暴露于缓冲液（CTRL），NACA，ERGO或N-乙酰半胱氨酸（NAC;阳性对照）。在37摄氏度下使用10 mM在体外进行治疗60分钟。治疗后，我们确定了肌肉的力频率和疲劳特性。结果：与CTRL和NAC相比，ERGO的力-频率关系向左移动，而NACA的力-频率关系向右移动。各组之间的最大强直肌力量相似。疲劳试验期间的总力时积分（FTI; Nscm）被NACA降低（420 +/- 35，P <0.05），不受ERGO的影响（657 +/- 53），而被NAC升高（P < 0.05），而CTRL（581 +/- 54）。疲劳试验期间的收缩率（dF / dtMAX）不受任何测试方法的影响。 NAC，而不是NACA或ERGO，延迟了疲劳期间肌肉松弛（dF / dtMIN）的减慢。结论：总而言之，NACA和ERGO不会延迟骨骼肌的体外疲劳。我们得出的结论是，这些抗氧化剂不太可能改善人类的运动表现。

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