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首页> 外文期刊>Medicine and science in sports and exercise >Aerobic exercise alters skeletal muscle molecular responses to resistance exercise
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Aerobic exercise alters skeletal muscle molecular responses to resistance exercise

机译：有氧运动改变骨骼肌对抵抗运动的分子反应

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Purpose: This study assessed the influence of an acute aerobic exercise bout on molecular responses to subsequent resistance exercise (RE). Methods: Nine physically active men performed a 45-min one-legged cycle ergometry exercise and 4 × 7 maximal concentric-eccentric knee extensions for each leg 6 h later. Thus, one limb was subjected to aerobic and resistance exercise (AE+RE), and the contralateral limb to resistance exercise (RE) only. Knee extensor peak power was determined. Biopsies were obtained from the m vastus lateralis before (PRE) and 15 min (POST1) and 3 h after RE. Analysis determined glycogen content, mRNA levels (vascular endothelial growth factor, peroxisome proliferator-activated receptor-γ coactivator-1, muscle RING-finger protein-1, atrogin-1, myostatin), and phosphorylated proteins (mammalian target of rapamycin, p70S6 kinase, ribosomal protein S6, eukaryotic elongation factor 2). Results: Peak power was similar in AE + RE and RE. After RE, the time course of glycogen utilization and protein signaling was similar across legs. However, phosphorylation of mammalian target of rapamycin and p70S6 kinase was elevated in AE + RE versus RE (main effect, P < 0.05). Vascular endothelial growth factor and peroxisome proliferator-activated receptor-γ coactivator-1 were higher in AE + RE than in RE at PRE and POST1 (P < 0.05). Myostatin was lower in AE + RE versus RE at PRE and POST1 (P < 0.05) and downregulated after resistance exercise only. Atrogin-1 was higher in AE + RE than in RE at PRE and POST1 (P < 0.05) and decreased after RE in AE + RE. Muscle RING-finger protein-1 was similar across legs. No difference for any marker was evident 3 h after RE. Conclusions: These results suggest that acute aerobic exercise alters molecular events regulating muscle protein turnover during the early recovery period from subsequent RE.
机译：目的：本研究评估了急性有氧运动对分子对后续抵抗运动（RE）分子反应的影响。方法：9名体育锻炼的男性在6小时后的每条腿上进行了45分钟的单腿测功运动，每条腿最大进行了4×7的同心-偏心膝关节伸展。因此，一个肢体进行了有氧和抵抗运动（AE + RE），而对侧肢只进行了抵抗运动（RE）。确定膝伸肌的峰值功率。在RE之前（PRE），15min（POST1）和RE之后3h，从外侧肌取活检。分析确定糖原含量，mRNA水平（血管内皮生长因子，过氧化物酶体增殖物激活的受体-γcoactivator-1，肌肉RING-手指蛋白-1，atrogin-1，肌生长抑制素）和磷酸化蛋白（哺乳动物雷帕霉素靶标，p70S6激酶） ，核糖体蛋白S6，真核生物延伸因子2）。结果：AE + RE和RE中的峰值功率相似。 RE后，各腿之间糖原利用和蛋白质信号传导的时间过程相似。然而，雷帕霉素和p70S6激酶的哺乳动物靶标的磷酸化在AE + RE中相对于RE有所提高（主要作用，P <0.05）。在PRE和POST1时，AE + RE中的血管内皮生长因子和过氧化物酶体增殖物激活的受体-γcoactivator-1高于RE（P <0.05）。在PRE和POST1时，AE + RE中的Myostatin相对于RE较低（P <0.05），并且仅在抵抗运动后才被下调。 AE + RE中的Atrogin-1高于PRE和POST1中的RE（P <0.05），而AE + RE中的Atrogin-1降低。腿部肌肉的RING-手指蛋白1相似。 RE后3小时，任何标记物均无明显差异。结论：这些结果表明，急性有氧运动在随后的RE的早期恢复期改变了调节肌肉蛋白质更新的分子事件。

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